Seladin 1 Products

Description

Seladin 1 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Bioinformatics

Entrez	1718 Human
Uniprot	NM_014762 Human NP_055577.1 Human Q15392 Human
Product By Gene ID	1718
Alternate Names	24-dehydrocholesterol reductaseNbla03646 DCE desmosterol-to-cholesterol enzyme Diminuto/dwarf1 homolog EC 1.3.1.72 KIAA0018SELADIN1 seladin 1,3-beta-hydroxysterol delta-24-reductase Seladin-1 seladin-1 selective AD indicator 1,3 beta-hydroxysterol delta 24-reductase

Diseases related to Seladin 1

Discover more about diseases related to Seladin 1.

Alzheimer's Disease
Malignant Neoplasms
Malignant Neoplasm Of Prostate
Neoplasms
Prostatic Neoplasms
Neuroblastoma
Hepatitis
Carcinoma
Hepatitis C
Neurodegenerative Disorders
Neoplasm Metastasis
Inflammation
Liver Carcinoma
Nerve Degeneration
Tissue Adhesions
Adenoma
Hypercholesterolemia
Adrenal Cortical Adenoma
Pituitary Diseases
Congenital Absence

Pathways for Seladin 1

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Pathogenesis
Neuroprotection
Cell Proliferation
Secretion
Response To Oxidative Stress
Cholesterol Homeostasis
Transport
Aging
Localization
Cell Growth
Cell Adhesion
Cell Differentiation
Methylation
Cell Death
Hyperphosphorylation
Electron Transport
Cellular Homeostasis
Immune Response
Skin Development
Chondrocyte Hypertrophy

PTMs for Seladin 1

Learn more about PTMs related to Seladin 1.

Cleavage
Phosphorylation
Acetylation
Reduction
Methylation
Glycosylation
Dephosphorylation
Ribosylation
Ubiquitination

Bioinformatics Tool for Seladin 1

Discover related pathways, diseases and genes to Seladin 1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.