Seladin 1 Antibody

Images

 
Western Blot: Seladin 1 Antibody [NBP1-32247] - Sample (30 ug of whole cell lysate) A: A431 7. 5% SDS PAGE Seladin 1 antibody, antibody diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: Seladin 1 Antibody [NBP1-32247] - Analysis of HeLa, using Seladin 1 antibody at 1:200 dilution.
Immunohistochemistry-Paraffin: Seladin 1 Antibody [NBP1-32247] - Paraffin-embedded rat adrenal gland. Seladin 1 antibody [N1C2] diluted at 1:500.
Western Blot: Seladin 1 Antibody [NBP1-32247] - Sample (50 ug of whole cell lysate) A: Mouse brain 7. 5% SDS PAGE; antibody diluted at 1:1000.
Immunohistochemistry-Paraffin: Seladin 1 Antibody [NBP1-32247] - Paraffin-embedded SW480 xenograft, using antibody at 1:100 dilution.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, BvSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.71 mg/ml

Order Details

Seladin 1 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human Seladin 1. The exact sequence is proprietary.
Localization
Endoplasmic reticulum membrane, Golgi apparatus membrane
Predicted Species
Porcine (95%), Bovine (96%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DHCR24
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
60 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Zebrafish (82%), Xenopus laevis (81%), Chicken (80%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.71 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Seladin 1 Antibody

  • 24-dehydrocholesterol reductaseNbla03646
  • DCE
  • desmosterol-to-cholesterol enzyme
  • Diminuto/dwarf1 homolog
  • EC 1.3.1.72
  • KIAA0018SELADIN1
  • seladin 1,3-beta-hydroxysterol delta-24-reductase
  • seladin-1
  • selective AD indicator 1,3 beta-hydroxysterol delta 24-reductase

Background

This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol DHCR24