S100A/B Antibody (D28-E)

Images

 
Immunohistochemistry-Paraffin: S100A/B Antibody (D28-E) [NBP1-30154] - S100A/B Antibody (D28-E) human breast tissue stained with S100A1 Antibody - strong positive immunostaining of the outer myoepithelial cell component ...read more
Immunohistochemistry-Paraffin: S100A/B Antibody (D28-E) [NBP1-30154] - S100A/B Antibody (D28-E) human neurofibroma tissue stained with S100A1 Antibody - positive immunostaining of tumor cells and peripheral nerve.
Immunohistochemistry-Paraffin: S100A/B Antibody (D28-E) [NBP1-30154] - S100A/B Antibody (D28-E) skin melanoma tissue stained with S100A1 Antibody - strong positive immunostaining of melanoma cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-Fr, IHC-P
Clone
D28-E
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

S100A/B Antibody (D28-E) Summary

Immunogen
Peptide derived from C-terminal sequence of human S100A/B protein.
Specificity
This antibody detects S100A and S100B monomers, the alpha-beta heterodimer, and also the beta-beta homodimer
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
S100A1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:100-1:200
  • Immunohistochemistry-Paraffin 1:100-1:200
Application Notes
For use in Immunohistochemistry frozen and paraffin embedded sections. For 0.1ml, 0.5ml, and 1.0ml sizes, use recommended dilutions. For 7.0ml and 15.0ml sizes, products should be used undiluted.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
20mM Tris/HCl (pH 8.0) and 20 mg/ml BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

The 7mL and 15mL sizes that this product is available in is a pre-diluted size and no additional dilutions are required before using this item for the intended application.

Alternate Names for S100A/B Antibody (D28-E)

  • protein S100-A1
  • S100 alpha
  • S100 calcium binding protein A1
  • S100 calcium-binding protein A1S100
  • S-100 protein alpha chain
  • S-100 protein subunit alpha
  • S100 protein, alpha polypeptide
  • S100A
  • S100-alpha

Background

S100A/B belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100A/B protein may function in stimulation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. Immunoreactive S100 protein localizes in the cytoplasm and nuclei of astrocytes, Schwann's cells, ependymomas and astrogliomas. Ganglion cells do not stain for S100A/B protein. S100A/B can be detected in almost all benign naevi and malignant melanocytic tumors of the skin, and in Langerhans cells in the skin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol S100A1
Entrez
Uniprot