Predicted cross-reactivity based on sequence identity: Rhesus Monkey (100%), Xenopus laevis (95%).
Alternate Names for RPSA Antibody
37 kDa laminin receptor precursor
37/67 kDa laminin receptor
67 kDa laminin receptor
67kD, ribosomal protein SA
Colon carcinoma laminin-binding protein
LAMBR37 kDa laminin receptor
laminin binding protein
laminin receptor 1 (67kD, ribosomal protein SA)
Laminin receptor 1
Laminin-binding protein precursor p40
LAMR140S ribosomal protein SA
Multidrug resistance-associated protein MGr1-Ag
ribosomal protein SA
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.