Recombinant Human BDNF Protein

Equivalent bioactivity of CHO-derived (11166-BD) and Sf 21 (baculovirus)-derived (Catalog # 248-BDB) Recombinant Human BDNF proteins as measured in a cell proliferation assay using BaF mouse pro-B cells transfected with TrkB.

• Reactivity: Hu, Mu, Rt, Ca, Eq
• Applications: Binding Activity, Bioactivity

Recombinant Human BDNF Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using BaF mouse pro-B cells transfected with TrkB. The ED₅₀ for this effect is 0.2-2 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human TrkB Fc Chimera (Catalog # 688-TK) is coated at 1 μg/mL, Recombinant Human BDNF binds with an apparent K_d <1 nM.
• Source: Spodoptera frugiperda, Sf 21 (baculovirus)-derived BDNF protein
  His129-Arg247
  Accession # P23560
  100% sequence homology with Mouse, Rat, Canine, Equine and all other mammalian proteins examined.
• Accession #: P23560
• N-terminal Sequence: His129
• Protein/Peptide Type: Recombinant Proteins
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Binding Activity2
  • Bioactivity
• Theoretical MW: 13.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 13-14 kDa, under reducing conditions.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and NaCl with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute 5 µg vials at 100 µg/mL in water. Reconstitute 10 µg or larger vials at 250 µg/mL in water.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human BDNF Protein

• Abrineurin
• ANON2
• BDNF
• brain-derived neurotrophic factor
• BULN2
• MGC34632
• Neurotrophin

Background

Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins (1, 2). All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive BDNF is predicted to be a non-covalently linked homodimer. BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. The amino acid sequence of mature BDNF is identical in all mammals examined. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye and placenta. In addition, low levels of BDNF expression are also found in the pituitary gland, spinal cord, heart, lung and skeletal muscle. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor (3). The BDNF signaling pathway utilizes both AKT and ERK pathways to exert its pleiotrophic effects in the central nervous system. BDNF is widely used in cell culture to support neuronal cell differentiation and survival. It also promotes differentiation of pluripotent stem cells into neural progenitor cells.

1. Eide, F.F. et al. (1993) Exp. Neurol. 121:200.
2. Snider, W.D. (1994) Cell 77:627.
3. Barbacid, M. (1994) J. Neurobiol. 25:1386.

Publications for BDNF (248-BDB)(226)

Publications using 248-BDB

• Tam, KW;Wong, CY;Wu, KL;Lam, G;Liang, X;Wong, WT;Li, MT;Liu, WY;Cai, S;Shea, GK;Shum, DK;Chan, YS; IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries Cells 2023-05-25 [PMID: 37296600] (Bioassay, Human)
• Dell'Amico, C;Angulo Salavarria, MM;Takeo, Y;Saotome, I;Dell'Anno, MT;Galimberti, M;Pellegrino, E;Cattaneo, E;Louvi, A;Onorati, M; Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors eLife 2023-06-05 [PMID: 37272619] (Bioassay, Human)
• W Xu, X Xu, L Yao, B Xue, H Xi, X Cao, G Piao, S Lin, X Wang VEGFA-modified DPSCs combined with LC-YE-PLGA NGCs promote facial nerve injury repair in rats Heliyon, 2023-03-28;9(4):e14626. 2023-03-28 [PMID: 37095964] (Bioassay, Rat)
• L Naulé, A Mancini, SA Pereira, BM Gassaway, JR Lydeard, JC Magnotto, HK Kim, J Liang, C Matos, SP Gygi, FT Merkle, RS Carroll, AP Abreu, UB Kaiser MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity JCI Insight, 2023-04-24;8(8):. 2023-04-24 [PMID: 37092553] (Bioassay, Human)
• SD Sharma, BK Reddy, R Pal, TE Ritakari, JD Cooper, BT Selvaraj, PC Kind, S Chandran, DJA Wyllie, S Chattarji Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons Cell Reports, 2023-04-04;42(4):112344. 2023-04-04 [PMID: 37018073] (Bioassay, Human)
• Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung&#039;s disease Cell Stem Cell, 2023;30(3):264-282.e9. 2023 [PMID: 36868194] (Bioassay, Human)
• Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung&#039;s disease Cell Stem Cell, 2023-03-02;30(3):264-282.e9. 2023-03-02 [PMID: 36868194] (Bioassay, Human)
• YW Jun, S Lee, BK Ban, JA Lee, FB Gao Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis Autophagy, 2023-02-27;0(0):1-17. 2023-02-27 [PMID: 36849436] (Bioassay, Human)
• EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798415] (Bioassay, Human)
• GR Linares, Y Li, WH Chang, J Rubin-Sigl, S Mendonca, S Hong, Y Eoh, W Guo, YH Huang, J Chang, S Tu, N Dorjsuren, M Santana, ST Hung, J Yu, J Perez, M Chickering, TY Cheng, CC Huang, SJ Lee, HJ Deng, KT Bach, K Gray, V Subramanya, J Rosenfeld, SV Alworth, H Goodarzi, JK Ichida SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS Cell Stem Cell, 2023-02-02;30(2):171-187.e14. 2023-02-02 [PMID: 36736291] (Bioassay, Human)
• O Pietiläine, A Trehan, D Meyer, J Mitchell, M Tegtmeyer, V Valakh, H Gebre, T Chen, E Vartiainen, SL Farhi, K Eggan, SA McCarroll, R Nehme Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons Cell Reports, 2023-01-12;42(1):111988. 2023-01-12 [PMID: 36640364] (Bioassay, Human)
• Z Álvarez, JA Ortega, K Sato, IR Sasselli, AN Kolberg-Ed, R Qiu, KA Marshall, TP Nguyen, CS Smith, KA Quinlan, V Papakis, Z Syrgiannis, NA Sather, C Musumeci, E Engel, SI Stupp, E Kiskinis Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons Cell Stem Cell, 2023-01-12;0(0):. 2023-01-12 [PMID: 36638801] (Bioassay, Human)
• CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendra, L Peng, H Oguro, J Kanaujiya, J Zou, D Sebesta, G Pratt, E Cross, J Blockwick, P Buxton, L Kinner-Bib, C Medura, C Tompkins, S Hughes, M Santiana, F Faghri, MA Nalls, D Vitale, S Ballard, YA Qi, DM Ramos, KM Anderson, J Stadler, P Narayan, J Papademetr, L Reilly, MP Nelson, S Aggarwal, LU Rosen, P Kirwan, V Pisupati, SL Coon, SW Scholz, T Priebe, M Öttl, J Dong, M Meijer, LJM Janssen, VS Lourenco, R van der Ka, D Crusius, D Paquet, AC Raulin, G Bu, A Held, BJ Wainger, RMC Gabriele, JM Casey, S Wray, D Abu-Bonsra, CL Parish, MS Beccari, DW Cleveland, E Li, IVL Rose, M Kampmann, C Calatayud, P Verstreken, L Heinrich, MY Chen, B Schüle, D Dou, ELF Holzbaur, MC Zanellati, R Basundra, M Deshmukh, S Cohen, R Khanna, M Raman, ZS Nevin, M Matia, J Van Lent, V Timmerman, BR Conklin, K Johnson Ch, K Zhang, S Funes, DA Bosco, L Erlebach, M Welzer, D Kronenberg, G Lyu, E Arenas, E Coccia, L Sarrafha, T Ahfeldt, JC Marioni, WC Skarnes, MR Cookson, ME Ward, FT Merkle A reference human induced pluripotent stem cell line for large-scale collaborative studies Cell Stem Cell, 2022-12-01;29(12):1685-1702.e22. 2022-12-01 [PMID: 36459969] (Bioassay, Human)
• JR Herdy, L Traxler, RK Agarwal, L Karbacher, JCM Schlachetz, L Boehnke, D Zangwill, D Galasko, CK Glass, J Mertens, FH Gage Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer&#039;s disease Cell Stem Cell, 2022-12-01;29(12):1637-1652.e6. 2022-12-01 [PMID: 36459967] (Bioassay, Human)
• HF Wu, W Yu, K Saito-Diaz, CW Huang, J Carey, F Lefcort, GW Hart, HX Liu, N Zeltner Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models Nature Communications, 2022-11-17;13(1):7032. 2022-11-17 [PMID: 36396637] (Bioassay, Human)
• G Kim, L Nakayama, JA Blum, T Akiyama, S Boeynaems, M Chakrabort, J Couthouis, E Tassoni-Ts, CM Rodriguez, MC Bassik, AD Gitler Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2 Cell Reports, 2022-10-25;41(4):111508. 2022-10-25 [PMID: 36288714] (Bioassay, Human)
• C Seah, MS Breen, T Rusielewic, HN Bader, C Xu, CJ Hunter, B McCarthy, PJM Deans, M Chattopadh, J Goldberg, F Desarnaud, I Makotkine, JD Flory, LM Bierer, M Staniskyte, NYSCF Glob, SA Noggle, LM Huckins, D Paull, KJ Brennand, R Yehuda Modeling gene � environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression Nature Neuroscience, 2022-10-20;25(11):1434-1445. 2022-10-20 [PMID: 36266471] (Bioassay, Human)
• Y Chen, Q Yin, XY Cheng, JR Zhang, H Jin, K Li, CJ Mao, F Wang, HZ Bei, CF Liu G2019S LRRK2 Mutation Enhances MPP+-Induced Inflammation of Human Induced Pluripotent Stem Cells-Differentiated Dopaminergic Neurons Frontiers in Neuroscience, 2022-07-06;16(0):947927. 2022-07-06 [PMID: 35873822] (Bioassay, Human)
• MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells Oncogene, 2022-02-21;31(0):100852. 2022-02-21 [PMID: 35782608] (Bioassay, Human)
• MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1 PLoS ONE, 2022-07-01;17(7):e0269683. 2022-07-01 [PMID: 35776705] (Bioassay, Human)
• M Häkli, S Jäntti, T Joki, L Sukki, K Tornberg, K Aalto-Setä, P Kallio, M Pekkanen-M, S Narkilahti Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip International Journal of Molecular Sciences, 2022-03-15;23(6):. 2022-03-15 [PMID: 35328569] (Bioassay, Human)
• N Moriarty, CW Gantner, CPJ Hunt, CM Ermine, S Frausin, S Viventi, DA Ovchinniko, D Kirik, CL Parish, LH Thompson A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells Cell Stem Cell, 2022-02-17;29(3):434-448.e5. 2022-02-17 [PMID: 35180398] (Bioassay, Human)
• MC Bufalo, MES Almeida, JR Jensen, C DeOcesano-, F Lichtenste, G Picolo, AM Chudzinski, SC Sampaio, Y Cury, VO Zambelli Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds Cells, 2022-01-12;11(2):. 2022-01-12 [PMID: 35053363] (Bioassay, Human)
• C Vajhøj, B Schmid, A Alik, R Melki, K Fog, B Holst, TC Stummann Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T alpha-synuclein levels and aggregation PLoS ONE, 2021-12-21;16(12):e0261536. 2021-12-21 [PMID: 34932569] (Bioassay, Human)
• A Dravid, B Raos, D Svirskis, SJ O'Carroll Optimised techniques for high-throughput screening of differentiated SH-SY5Y cells and application for neurite outgrowth assays Scientific Reports, 2021-12-14;11(1):23935. 2021-12-14 [PMID: 34907283] (Bioassay, Human)
• F Rousset, D Schmidbaue, S Fink, Y Adel, B Obexer, M Müller, R Glueckert, H Löwenheim, P Senn Phoenix auditory neurons as 3R cell model for high throughput screening of neurogenic compounds Hearing research, 2021-11-14;414(0):108391. 2021-11-14 [PMID: 34844170] (Bioassay, Mouse)
• AM Earley, LF Burbulla, D Krainc, R Awatramani Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons Scientific Reports, 2021-11-15;11(1):22257. 2021-11-15 [PMID: 34782629] (Bioassay, Human)
• P Sabatier, CM Beusch, AA Saei, M Aoun, N Moruzzi, A Coelho, N Leijten, M Nordenskjö, P Micke, D Maltseva, AG Tonevitsky, V Millischer, J Carlos Vil, S Kadekar, M Gaetani, K Altynbekov, A Kel, PO Berggren, O Simonson, KH Grinnemo, R Holmdahl, S Rodin, RA Zubarev An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation Nature Communications, 2021-11-12;12(1):6558. 2021-11-12 [PMID: 34772928] (Bioassay, Human)
• A Gonzalez-R, E Waloschkov, A Mikroulis, Z Kokaia, J Bengzon, M Ledri, M Andersson, M Kokaia Human stem cell-derived GABAergic neurons functionally integrate into human neuronal networks Scientific Reports, 2021-11-11;11(1):22050. 2021-11-11 [PMID: 34764308] (Bioassay, Human)
• GP Sharma, AC Frei, J Narayanan, T Gasperetti, D Veley, A Amjad, K Albano, BL Fish, HA Himburg Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells PLoS ONE, 2021-10-25;16(10):e0259042. 2021-10-25 [PMID: 34695155] (In Vivo, Mouse)
• Y Sonobe, J Aburas, G Krishnan, AC Fleming, G Ghadge, P Islam, EC Warren, Y Gu, MW Kankel, AEX Brown, E Kiskinis, TF Gendron, FB Gao, RP Roos, P Kratsios A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation Nature Communications, 2021-10-15;12(1):6025. 2021-10-15 [PMID: 34654821] (Bioassay, Human)
• X Reed, MM Cobb, G Skinbinski, D Roosen, A Kaganovich, J Ding, S Finkbeiner, MR Cookson Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched Stem Cell Research, 2021-10-03;56(0):102558. 2021-10-03 [PMID: 34626895] (Cell Culture, Human)
• A Petkova-Tu, N Gödecke, J Viotti, M Korte, T Dresbach Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling Bmc Biology, 2021-09-27;19(1):215. 2021-09-27 [PMID: 34579720] (Bioassay, Human)
• P Chennampal, A Sayed-Zahi, P Soundarara, J Sharp, GA Cox, SD Collins, RL Smith A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin Scientific Reports, 2021-09-13;11(1):18168. 2021-09-13 [PMID: 34518579] (Bioassay, Transgenic Mouse)
• J Sun, DY Shin, M Eiseman, AR Yallowitz, N Li, S Lalani, Z Li, M Cung, S Bok, S Debnath, SJ Marquez, TE White, AG Khan, IC Lorenz, JH Shim, FS Lee, R Xu, MB Greenblatt SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts Nature Communications, 2021-07-29;12(1):4611. 2021-07-29 [PMID: 34326333] (Bioassay, Human)
• YZ Le, B Xu, AJ Chucair-El, H Zhang, M Zhu VEGF Mediates Retinal M�ller Cell Viability and Neuroprotection through BDNF in Diabetes Biomolecules, 2021-05-10;11(5):. 2021-05-10 [PMID: 34068807] (Bioassay, Rat)
• IR de Luzy, KCL Law, N Moriarty, CPJ Hunt, JC Durnall, LH Thompson, A Nagy, CL Parish Human stem cells harboring a suicide gene improve the�safety and standardisation of neural transplants in Parkinsonian rats Nature Communications, 2021-05-27;12(1):3275. 2021-05-27 [PMID: 34045451] (Bioassay, Human)
• ZT Olmsted, JL Paluh Co-development of central and peripheral neurons with trunk mesendoderm in human elongating multi-lineage organized gastruloids Nature Communications, 2021-05-21;12(1):3020. 2021-05-21 [PMID: 34021144] (Bioassay, Human)
• V Padmanabha, H Liu, G Ciceri, J Jungverdor, G Frishman, J Tchieu, GY Cederquist, I Rothenaign, K Schorpp, L Klepper, RM Walsh, TW Kim, D Cornacchia, A Ruepp, J Mayer, K Hadian, D Frishman, L Studer, M Vincendeau Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3 Cell Stem Cell, 2021-05-04;0(0):. 2021-05-04 [PMID: 33951478] (Bioassay, Human)
• J Mertens, JR Herdy, L Traxler, ST Schafer, JCM Schlachetz, L Böhnke, DA Reid, H Lee, D Zangwill, DP Fernandes, RK Agarwal, R Lucciola, L Zhou-Yang, L Karbacher, F Edenhofer, S Stern, S Horvath, ACM Paquola, CK Glass, SH Yuan, M Ku, A Szücs, LSB Goldstein, D Galasko, FH Gage Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer&#039;s patients Cell Stem Cell, 2021-04-27;0(0):. 2021-04-27 [PMID: 33910058] (Bioassay, Human)
• GLM Arruda, H Vigerelli, MC Bufalo, GB Longato, RV Veloso, VO Zambelli, G Picolo, Y Cury, AC Morandini, AC Marques, JM Sciani Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron&#039;s Connection: A Possible Neuroprotector Effect BioMed Research International, 2021-03-04;2021(0):8855248. 2021-03-04 [PMID: 33748281] (Bioassay, Human)
• CV Latchouman, MI Betancur, GA Simchick, MK Sun, R Forghani, CE Lenear, A Ahmed, R Mohankumar, N Balaji, HD Mason, SA Archer-Har, P Azadi, PV Holmes, Q Zhao, RV Bellamkond, L Karumbaiah Engineered glycomaterial implants orchestrate large-scale functional repair of brain tissue chronically after severe traumatic brain injury Science Advances, 2021-03-05;7(10):. 2021-03-05 [PMID: 33674306] (Bioassay, Rat)
• S Zierold, K Buschmann, S Gachkar, ML Bochenek, D Velmeden, L Hobohm, CF Vahl, K Schäfer Brain-Derived Neurotrophic Factor Expression and Signaling in Different Perivascular Adipose Tissue Depots of Patients With Coronary Artery Disease Journal of the American Heart Association, 2021-03-05;10(6):e018322. 2021-03-05 [PMID: 33666096] (Bioassay, Human)
• X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment Cell Reports, 2021-03-02;34(9):108802. 2021-03-02 [PMID: 33657377] (Bioassay, Human)
• E Solomon, K Davis-Ande, B Hovde, S Micheva-Vi, JF Harris, S Twary, R Iyer Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation BMC molecular and cell biology, 2021-02-18;22(1):13. 2021-02-18 [PMID: 33602141] (Bioassay, Human)
• TW Kim, J Piao, SY Koo, S Kriks, SY Chung, D Betel, ND Socci, SJ Choi, S Zabierowsk, BN Dubose, EJ Hill, EV Mosharov, S Irion, MJ Tomishima, V Tabar, L Studer Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use Cell Stem Cell, 2021-02-04;28(2):343-355.e5. 2021-02-04 [PMID: 33545081] (Bioassay, Human)
• T Kurosaki, N Imamachi, C Pröschel, S Mitsutomi, R Nagao, N Akimitsu, LE Maquat Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay Nature Cell Biology, 2021-01-08;23(1):40-48. 2021-01-08 [PMID: 33420492] (Bioassay, Human)
• L Honkamäki, T Joki, NA Grigoryev, K Levon, L Ylä-Outine, S Narkilahti Novel method to produce a layered 3D scaffold for human pluripotent stem cell-derived neuronal cells Journal of neuroscience methods, 2020-12-17;350(0):109043. 2020-12-17 [PMID: 33345946] (Bioassay, Human)
• D Jutzi, S Campagne, R Schmidt, S Reber, J Mechtershe, F Gypas, C Schweingru, M Colombo, C von Schroe, FE Loughlin, A Devoy, E Hedlund, M Zavolan, FH Allain, MD Ruepp Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis Nature Communications, 2020-12-11;11(1):6341. 2020-12-11 [PMID: 33311468] (Bioassay, Human)
• S Lito, A Sidibe, S Ilmjarv, P Burda, M Baumgartne, B Wehrle-Hal, KH Krause, A Marteyn Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors Cells, 2020-12-03;9(12):. 2020-12-03 [PMID: 33287330] (Bioassay, Human)
• N Ramesh, EL Daley, AM Gleixner, JR Mann, S Kour, D Mawrie, EN Anderson, J Kofler, CJ Donnelly, E Kiskinis, UB Pandey RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3 Acta Neuropathol Commun, 2020-10-31;8(1):177. 2020-10-31 [PMID: 33129345] (Cell Culture, Human)
• KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function Cell Stem Cell, 2020-10-21;0(0):. 2020-10-21 [PMID: 33091368] (Bioassay, Human)
• JW Kim, X Yin, A Jhaldiyal, MR Khan, I Martin, Z Xie, T Perez-Rose, M Kumar, L Abalde-Atr, J Xu, L Chen, SM Eacker, DJ Surmeier, NT Ingolia, TM Dawson, VL Dawson Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis Cell Stem Cell, 2020-08-25;27(4):633-645.e7. 2020-08-25 [PMID: 32846140] (Bioassay, Human)
• KM Prautsch, A Schmidt, V Paradiso, DJ Schaefer, R Guzman, DF Kalbermatt, S Madduri Modulation of Human Adipose Stem Cells&#039; Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro Cells, 2020-08-21;9(9):. 2020-08-21 [PMID: 32839392] (Bioassay, Cell Culture, Human)
• C Frick, S Fink, D Schmidbaue, F Rousset, H Eickhoff, A Tropitzsch, B Kramer, P Senn, R Glueckert, H Rask-Ander, KH Wiesmüller, H Löwenheim, M Müller Age-Dependency of Neurite Outgrowth in Postnatal Mouse Cochlear Spiral Ganglion Explants Brain Sci, 2020-08-21;10(9):. 2020-08-21 [PMID: 32839381] (Bioassay, Mouse)
• V Scheper, I Seidel-Eff, T Lenarz, T Stöver, G Paasche Consecutive Treatment with Brain-Derived Neurotrophic Factor and Electrical Stimulation Has a Protective Effect on Primary Auditory Neurons Brain sciences, 2020-08-15;10(8):. 2020-08-15 [PMID: 32824176] (Bioassay, Guinea Pig)
• K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates Sci Rep, 2020-08-20;10(1):14047. 2020-08-20 [PMID: 32820178] (Bioassay, Human)
• CA Tristan, P Ormanoglu, J Slamecka, C Malley, PH Chu, VM Jovanovic, Y Gedik, C Bonney, E Barnaeva, J Braisted, SK Mallanna, D Dorjsuren, MJ Iannotti, TC Voss, S Michael, A Simeonov, I Singeç Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells bioRxiv, 2020-08-03;0(0):. 2020-08-03 [PMID: 32793899] (Bioassay, Human)
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• Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O MicroRNA-based promotion of human neuronal differentiation and subtype specification. PLoS ONE, 2013-03-18;8(3):e59011. 2013-03-18 [PMID: 23527072] (Bioassay, Human)
• Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, Klein R Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci, 2013-03-20;33(12):5399-410. 2013-03-20 [PMID: 23516305] (Bioassay, Mouse)
• Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, Taylor C, Ghosh S, Price T BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state. Mol Pain, 2013-03-20;9(0):12. 2013-03-20 [PMID: 23510079] (Bioassay, In Vivo, Mouse)
• Dewitt J, Ochoa V, Urschitz J, Elston M, Moisyadi S, Nishi R Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line. Oncogene, 2013-03-04;33(8):977-85. 2013-03-04 [PMID: 23455321] (Bioassay, Human)
• Denis J, Gauthier M, Rachdi L, Aubert S, Giraud-Triboult K, Poydenot P, Benchoua A, Champon B, Maury Y, Baldeschi C, Scharfmann R, Pietu G, Peschanski M, Martinat C mTOR-dependent proliferation defect in human ES-derived neural stem cells affected by myotonic dystrophy type 1. J Cell Sci, 2013-02-26;126(0):1763-72. 2013-02-26 [PMID: 23444380] (Bioassay, Human)
• Corbett , Grant T, Roy , Avik, Pahan , Kalipada Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy. J Biol Chem, 2013-02-12;288(12):8299-312. 2013-02-12 [PMID: 23404502] (Bioassay, Mouse)
• Shim , Joong Hy, Lee , Tae Ryon, Shin , Dong Woo Enrichment and characterization of human dermal stem/progenitor cells by intracellular granularity. Stem Cells Dev, 2013-01-22;22(8):1264-74. 2013-01-22 [PMID: 23336432] (Bioassay, Human)
• Makino , Kenichi, Kawamura , Kazuhiro, Sato , Wataru, Kawamura , Nanami, Fujimoto , Toshio, Terada , Yukihiro Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling. PLoS ONE, 2012-07-23;7(7):e41049. 2012-07-23 [PMID: 22911740] (Bioassay, Human)
• Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Human, Mouse)
• Moore RN, Cherry JF, Mathur V E-cadherin-expressing feeder cells promote neural lineage restriction of human embryonic stem cells. Stem Cells Dev., 2011-06-01;21(1):30-41. 2011-06-01 [PMID: 21469943] (Bioassay, Human)
• Whitfield TW, Shi X, Sun WL The suppressive effect of an intra-prefrontal cortical infusion of BDNF on cocaine-seeking is Trk receptor and extracellular signal-regulated protein kinase mitogen-activated protein kinase dependent. J. Neurosci., 2011-01-19;31(3):834-42. 2011-01-19 [PMID: 21248106] (In Vivo, Rat)
• Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D'Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chedotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J. Neurosci., 2010-11-10;30(45):15052-66. 2010-11-10 [PMID: 21068311] (Bioassay, Mouse)
• Delcroix GJ, Curtis KM, Schiller PC, Montero-Menei CN EGF and bFGF pre-treatment enhances neural specification and the response to neuronal commitment of MIAMI cells. Differentiation, 2010-09-01;80(4):213-27. 2010-09-01 [PMID: 20813449] (Bioassay, Human)
• Berglind WJ, Whitfield TW, LaLumiere RT, Kalivas PW, McGinty JF A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens. J. Neurosci., 2009-03-25;29(12):3715-9. 2009-03-25 [PMID: 19321768] (In Vivo, Rat)
• Sun Y, Pollard S, Conti L, Toselli M, Biella G, Parkin G, Willatt L, Falk A, Cattaneo E, Smith A Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol. Cell. Neurosci., 2008-03-18;38(2):245-58. 2008-03-18 [PMID: 18450476] (Bioassay, Human)
• Kajiya M, Shiba H, Fujita T, Ouhara K, Takeda K, Mizuno N, Kawaguchi H, Kitagawa M, Takata T, Tsuji K, Kurihara H Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts. J. Biol. Chem., 2008-04-03;283(23):16259-67. 2008-04-03 [PMID: 18390540] (Bioassay, Human)
• Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev., 2008-01-15;22(2):152-65. 2008-01-15 [PMID: 18198334] (Bioassay, Human)
• Samah B, Porcheray F, Gras G Neurotrophins modulate monocyte chemotaxis without affecting macrophage function. Clin. Exp. Immunol., 2008-01-08;151(3):476-86. 2008-01-08 [PMID: 18190610] (Bioassay, Human)
• Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Stem Cells, 2007-09-27;26(1):163-72. 2007-09-27 [PMID: 17901404] (Bioassay, Rat)
• Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development, 2007-09-01;134(18):3327-38. 2007-09-01 [PMID: 17720696] (Bioassay, Mouse)
• Berglind WJ, See RE, Fuchs RA, Ghee SM, Whitfield TW, Miller SW, McGinty JF A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats. Eur. J. Neurosci., 2007-07-25;26(3):757-66. 2007-07-25 [PMID: 17651427] (In Vivo, Rat)
• Di Lazzaro V, Profice P, Pilato F, Dileone M, Florio L, Tonali PA, Angelucci F BDNF plasma levels in acute stroke. Neurosci. Lett., 2007-06-08;422(2):128-30. 2007-06-08 [PMID: 17590513] (ELISA (Standard))
• Salero E, Hatten ME Differentiation of ES cells into cerebellar neurons. Proc. Natl. Acad. Sci. U.S.A., 2007-02-09;104(8):2997-3002. 2007-02-09 [PMID: 17293457] (Bioassay, Mouse)
• Paredes D, Granholm AC, Bickford PC Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. Brain Res., 2007-01-12;1141(0):56-64. 2007-01-12 [PMID: 17292337] (In Vivo, Rat)
• Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)
• Mohapel P, Frielingsdorf H, Haggblad J, Zachrisson O, Brundin P Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience, 2005-01-01;132(3):767-76. 2005-01-01 [PMID: 15837137] (In Vivo, Rat)
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Bioinformatics

• Uniprot:
  • P23560()