TrkC Antibody [Unconjugated]

Western blot shows lysates of mouse brain (cerebellum) tissue, mouse brain (cortex) tissue, and rat brain tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Mouse/Rat TrkC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1404) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). Specific bands were detected for TrkC at approximately 100 and 140 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Simple Western lane view shows lysates of mouse brain tissue, loaded at 0.2 mg/mL. Specific bands were detected for TrkC at approximately 111 and 159 kDa (as indicated) using 25 µg/mL of Goat Anti-Mouse/Rat TrkC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1404) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the12-230 kDa separation system.

Cra1/+ mice show no evidence of proprioceptive sensory neuron loss at symptomatic ages.A) Proprioceptive sensory neuron labeling and quantification with parvalbumin, (B) ER81, and (C) TrkC shows no difference between of +/+ and Cra1/+ mice at 6 months of age (Scale bar = 20 µm). D) Parvalbumin labeling of proprioceptive sensory neuron fibers within the spinal cord shows the central projection of these sensory neurons is intact in Cra1/+ mice (Scale bar = 20 µm; N = 3 animals per genotype). Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0016753), licensed under a CC-BY license. Not internally tested by R&D Systems.

Cra1/+ mice show no evidence of proprioceptive sensory neuron loss at symptomatic ages.A) Proprioceptive sensory neuron labeling and quantification with parvalbumin, (B) ER81, and (C) TrkC shows no difference between of +/+ and Cra1/+ mice at 6 months of age (Scale bar = 20 µm). D) Parvalbumin labeling of proprioceptive sensory neuron fibers within the spinal cord shows the central projection of these sensory neurons is intact in Cra1/+ mice (Scale bar = 20 µm; N = 3 animals per genotype). Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0016753), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Mu, Rt
• Applications: WB, Simple Western, IHC, B/N
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

TrkC Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse TrkC
  Cys32-Thr429
  Accession # Q6VNS1
• Specificity: Detects mouse TrkC in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human (rh) TrkC is observed and less than 2% cross‑reactivity with recombinant mouse TrkB, recombinant rat TrkA, and rhTrkA is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NTRK3
• Purity Statement: Antigen Affinity-purified
• Endotoxin Note: <0.10 EU per 1 μg of the antibody by the LAL method.

Applications/Dilutions

• Dilutions:
  • Blockade of Receptor-ligand Interaction
  • Immunohistochemistry 5-15 ug/mL
  • Simple Western 25 ug/mL
  • Western Blot 0.5 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TrkC Antibody [Unconjugated]

• EC 2.7.10
• EC 2.7.10.1
• ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
• ETV6-NTRK3 fusion
• gp145(trkC)
• GP145-TrkC
• Neurotrophic tyrosine kinase receptor type 3
• neurotrophic tyrosine kinase, receptor, type 3
• NT 3 receptor
• NT-3 growth factor receptor
• NTRK3
• TrkC tyrosine kinase
• TrkC
• trk-C
• TRKCneurotrophin 3 receptor
• tyrosine kinase receptor C

Background

The neurotrophins, including NGF, BDNF, NT‑3 and NT‑4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases (1, 2). p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. It binds all neurotrophins with low affinity to transduce cellular signaling pathways that synergize or antagonize those activated by the Trk receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT‑3, TrkB binds BDNF, NT‑3 and NT‑4/5, and TrkC only binds NT‑3 (1‑2). All Trk family proteins share a conserved, complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain (3). Natural splice variants of the different Trks, lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described (4). At the protein sequence level, Trks are highly conserved between species with the extracellular domains of human and mouse TrkC showing 94% amino acid sequence identity (5). The proteins also exhibit cross-species activity. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system (6).

1. Huang, E.J. and L.F. Reichardt (2003) Annu. Rev. Biochem. 72:609.
2. Dechant, G. (2001) Cell Tissue Res. 305:229.
3. Schneider, R. and M. Schweiger (1991) Oncogene 6:1807.
4. Ninkina, N. et al. (1997) J. Biol. Chem. 272:13019.
5. Menn, B. et al. (1998) J. Comp. Neurol. 401:47.
6. Shelton, D. et al. (1995) J. Neurosci. 15:477.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TrkC Antibody (AF1404)(70)

Publications using AF1404

• Koui, Y;Song, S;Dong, X;Mukouyama, YS; Local keratinocyte-nociceptor interactions enhance obesity-mediated small fiber neuropathy via NGF-TrkA-PI3K signaling axis bioRxiv : the preprint server for biology 2024-07-16 [PMID: 39372742] (Immunohistochemistry, Mouse, Transgenic Mouse)
• Cameron, B;Torres-Hernandez, L;Montague, VL;Lewis, KA;Smith, H;Fox, J;Guo, X;Kalb, RG;George, L; Titin is a nucleolar protein in neurons Research square 2024-03-04 [PMID: 38496572] (Immunohistochemistry, Mouse)
• N Frezel, M Ranucci, E Foster, H Wende, P Pelczar, R Mendes, RP Ganley, K Werynska, S d'Aquin, C Beccarini, C Birchmeier, HU Zeilhofer, H Wildner c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy Cell Reports, 2023-03-21;42(4):112295. 2023-03-21 [PMID: 36947543] (IHC, Mouse)
• Liu S, Xiang K, Yuan F, Xiang M Generation of self-organized autonomic ganglion organoids from fibroblasts iScience 3/1/2023 [PMID: 36922996]
• D Schmidbaue, S Fink, F Rousset, H Löwenheim, P Senn, R Glueckert Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial? International Journal of Molecular Sciences, 2023-01-19;24(3):. 2023-01-19 [PMID: 36768339] (IHC, Mouse)
• Karen A. Lindquist, Sergei Belugin, Anahit H. Hovhannisyan, Tatiana M. Corey, Adam Salmon, Armen N. Akopian Identification of Trigeminal Sensory Neuronal Types Innervating Masseter Muscle eNeuro 9/27/2021 [PMID: 34580157]
• Vladimir Vladimirovich Muzyka, Tudor Constantin Badea Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification Neural Development 12/1/2021 [PMID: 34548095]
• N Sultan, BA Scheven Exploring the potential application of dental pulp stem cells in neuroregenerative medicine Neural regeneration research, 2022-04-01;17(4):775-776. 2022-04-01 [PMID: 34472466] (Neutralization, Rat)
• Qi Tang, Meng‐Yao Xie, Yong‐Li Zhang, Ruo‐Yan Xue, Xiao‐Hui Zhu, Hua Yang Targeted deletion of Atoh8 results in severe hearing loss in mice genesis 9/1/2021 [PMID: 34402594]
• Qi Tang, Meng‐Yao Xie, Yong‐Li Zhang, Ruo‐Yan Xue, Xiao‐Hui Zhu, Hua Yang Targeted deletion of Atoh8 results in severe hearing loss in mice genesis 2021-09-01 [PMID: 34402594] (Immunohistochemistry, Mouse)
• Mark A. Landy, Megan Goyal, Helen C. Lai Nociceptor subtypes are born continuously over DRG development. Developmental Biology 11/1/2021 [PMID: 34352273]
• N Sultan, LE Amin, AR Zaher, ME Grawish, BA Scheven Dental pulp stem cells stimulate neuronal differentiation of PC12 cells Neural regeneration research, 2021-09-01;16(9):1821-1828. 2021-09-01 [PMID: 33510089] (Neutralization, Rat)
• V Kampanis, B Tolou-Dabb, L Zhou, W Roth, R Puttagunta Cyclic Stretch of Either PNS or CNS Located Nerves Can Stimulate Neurite Outgrowth Cells, 2020-12-28;10(1):. 2020-12-28 [PMID: 33379276] (ICC, Rat)
• A Escalante, R Klein Spinal Inhibitory Ptf1a-Derived Neurons Prevent Self-Generated Itch Cell Rep, 2020-11-24;33(8):108422. 2020-11-24 [PMID: 33238109] (IHC, Mouse)
• Graziana Gatto, Steeve Bourane, Xiangyu Ren, Stefania Di Costanzo, Peter K. Fenton, Priyabrata Halder et al. A Functional Topographic Map for Spinal Sensorimotor Reflexes Neuron 1/1/2021 [PMID: 33181065]
• L Faure, Y Wang, ME Kastriti, P Fontanet, KKY Cheung, C Petitpré, H Wu, LL Sun, K Runge, L Croci, MA Landy, HC Lai, GG Consalez, A de Chevign, F Lallemend, I Adameyko, S Hadjab Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates Nat Commun, 2020-08-21;11(1):4175. 2020-08-21 [PMID: 32826903] (IHC, Mouse)
• D Xiao, Q Deng, Y Guo, X Huang, M Zou, J Zhong, P Rao, Z Xu, Y Liu, Y Hu, Y Shen, K Jin, M Xiang Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts Sci Adv, 2020-05-29;6(22):eaaz5858. 2020-05-29 [PMID: 32523990] (ICC, IHC, Mouse)
• Katarzyna M. Targowska-Duda, Akihiko Ozawa, Zachariah Bertels, Andrea Cippitelli, Jason L. Marcus, Hanna K. Mielke-Maday et al. NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice Neuropharmacology 6/1/2020 [PMID: 32278976]
• P Pagella, J Catón, CT Meisel, TA Mitsiadis Ameloblastomas Exhibit Stem Cell Potential, Possess Neurotrophic Properties, and Establish Connections with Trigeminal Neurons Cells, 2020-03-06;9(3):. 2020-03-06 [PMID: 32155948] (IHC-P, Human)
• M Bohic, I Marics, C Santos, P Malapert, N Ben-Arie, C Salio, A Reynders, Y Le Feuvre, AJ Saurin, A Moqrich Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner Cell Rep, 2020-01-21;30(3):602-610.e6. 2020-01-21 [PMID: 31968239] (IF, Mouse)
• Sónia Paixão, Laura Loschek, Louise Gaitanos, Pilar Alcalà Alcalà Morales, Martyn Goulding, Rüdiger Klein Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements Neuron 11/1/2019 [PMID: 31586516]
• Yiqiao Wang, Haohao Wu, Pavel Zelenin, Paula Fontanet, Simone Wanderoy, Charles Petitpré et al. Muscle-selective RUNX3 dependence of sensorimotor circuit development Development 10/15/2019 [PMID: 31575648]
• Martina Dvorakova, Iva Macova, Romana Bohuslavova, Miroslava Anderova, Bernd Fritzsch, Gabriela Pavlinkova Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2 Developmental Biology 1/1/2020 [PMID: 31526806]
• Y Wang, H Wu, P Fontanet, S Codeluppi, N Akkuratova, C Petitpré, Y Xue-Franzé, K Niederreit, A Sharma, F Da Silva, G Comai, G Agirman, D Palumberi, S Linnarsson, I Adameyko, A Moqrich, A Schedl, G La Manno, S Hadjab, F Lallemend A cell fitness selection model for neuronal survival during development Nat Commun, 2019-09-12;10(1):4137. 2019-09-12 [PMID: 31515492] (ICC, Mouse)
• Greg A. Weir, Philippa Pettingill, Yukyee Wu, Galbha Duggal, Andrei-Sorin Ilie, Colin J. Akerman et al. The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing Frontiers in Molecular Neuroscience 7/17/2019 [PMID: 31379497]
• Greg A. Weir, Philippa Pettingill, Yukyee Wu, Galbha Duggal, Andrei-Sorin Ilie, Colin J. Akerman et al. The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing Frontiers in Molecular Neuroscience 2019-07-17 [PMID: 31379497] (Immunohistochemistry, Transgenic Mouse)
• D Acton, X Ren, S Di Costanz, A Dalet, S Bourane, I Bertocchi, C Eva, M Goulding Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch Cell Rep, 2019-07-16;28(3):625-639.e6. 2019-07-16 [PMID: 31315043] (IHC-Fr, Mouse)
• Mayur Patil, Anahit H. Hovhannisyan, Andi Wangzhou, Jennifer Mecklenburg, Wouter Koek, Vincent Goffin et al. Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex‐dependent Journal of Neuroendocrinology 8/1/2019 [PMID: 31231869]
• S Wiszniak, Q Schwarz Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration BMC Neurosci, 2019-04-29;20(1):21. 2019-04-29 [PMID: 31036074] (IHC-F, Mouse)
• A Takeoka, S Arber Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury Cell Rep, 2019-04-02;27(1):71-85.e3. 2019-04-02 [PMID: 30943416] (IHC, Mouse)
• S Desiderio, S Vermeiren, C Van Campen, S Kricha, E Malki, S Richts, EV Fletcher, T Vanwelden, BZ Schmidt, KA Henningfel, T Pieler, CG Woods, V Nagy, C Verfaillie, EJ Bellefroid Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA Cell Rep, 2019-03-26;26(13):3522-3536.e5. 2019-03-26 [PMID: 30917309] (ICC, Mouse)
• L Bartesaghi, Y Wang, P Fontanet, S Wanderoy, F Berger, H Wu, N Akkuratova, F Bouçanova, JJ Médard, C Petitpré, MA Landy, MD Zhang, P Harrer, C Stendel, R Stucka, M Dusl, ME Kastriti, L Croci, HC Lai, GG Consalez, A Pattyn, P Ernfors, J Senderek, I Adameyko, F Lallemend, S Hadjab, R Chrast PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis Cell Rep, 2019-03-26;26(13):3484-3492.e4. 2019-03-26 [PMID: 30917305] (IHC, Mouse)
• M Zhang, Y Wang, J Geng, S Zhou, B Xiao Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice Cell Rep, 2019-02-05;26(6):1419-1431.e4. 2019-02-05 [PMID: 30726728] (IHC, Mouse)
• MJ Patil, AH Hovhannisy, AN Akopian Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines PLoS ONE, 2018-06-04;13(6):e0198601. 2018-06-04 [PMID: 29864146] (IHC, Mouse)
• R Tashima, K Koga, M Sekine, K Kanehisa, Y Kohro, K Tominaga, K Matsushita, H Tozaki-Sai, Y Fukazawa, K Inoue, H Yawo, H Furue, M Tsuda Optogenetic Activation of Non-Nociceptive A? Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats eNeuro, 2018-02-15;5(1):. 2018-02-15 [PMID: 29468190] (IHC, Rat)
• AJ Alshawaf, S Viventi, W Qiu, G D'Abaco, B Nayagam, M Erlichster, G Chana, I Everall, J Ivanusic, E Skafidas, M Dottori Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Sci Rep, 2018-01-12;8(1):603. 2018-01-12 [PMID: 29330377] (ICC, Human)
• YA Bernal Sie, J Haseleu, A Kozlenkov, V Bégay, GR Lewin Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System Front Mol Neurosci, 2017-03-15;10(0):70. 2017-03-15 [PMID: 28360836] (IHC, Mouse)
• EA Price, A Krasowska-, KK Nanda, SJ Stachel, DA Henze Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway J. Neurosci. Methods, 2017-03-07;282(0):34-42. 2017-03-07 [PMID: 28279735] (ELISA Development (Capture), Rat)
• L Urien, S Gaillard, L Lo Re, P Malapert, M Bohic, A Reynders, A Moqrich Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain Sci Rep, 2017-02-27;7(0):43493. 2017-02-27 [PMID: 28240741] (IHC-Fr, Mouse)
• Marta Chaverra, Lynn George, Marc Mergy, Hannah Waller, Katharine Kujawa, Connor Murnion et al. The Familial Dysautonomia disease gene,Ikbkap/Elp1, is required in the developing and adult central nervous system Disease Models & Mechanisms 2017-05-01 [PMID: 28167615] (Immunohistochemistry, Mouse)
• Marta Chaverra, Lynn George, Marc Mergy, Hannah Waller, Katharine Kujawa, Connor Murnion et al. The Familial Dysautonomia disease gene,Ikbkap/Elp1, is required in the developing and adult central nervous system Disease Models & Mechanisms 5/1/2017 [PMID: 28167615]
• Amaury François, Sarah A. Low, Elizabeth I. Sypek, Amelia J. Christensen, Chaudy Sotoudeh, Kevin T. Beier et al. A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins Neuron 2/22/2017 [PMID: 28162807]
• Ariadna Arbat-Plan Endogenous Modulation of Trkb Signaling by Treadmill Exercise After Peripheral Nerve Injury Neuroscience, 2016-10-29;0(0):. 2016-10-29 [PMID: 27984178] (Western Blot, Rat)
• Fumiyasu Imai, Xiaoting Chen, Matthew T. Weirauch, Yutaka Yoshida Requirement for Dicer in Maintenance of Monosynaptic Sensory-Motor Circuits in the Spinal Cord Cell Reports 11/17/2016 [PMID: 27880894]
• Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy Sci Rep, 2016-11-17;6(0):37209. 2016-11-17 [PMID: 27853305] (Neutralization, Mouse)
• Sandra Pinet, Barbara Bessette, Nicolas Vedrenne, Aurélie Lacroix, Laurence Richard, Marie-Odile Jauberteau et al. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells Oncotarget 8/2/2016 [PMID: 27385098]
• EG Reed-Geagh, MC Wright, LA See, PC Adelman, KH Lee, HR Koerber, SM Maricich Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes J Neurosci, 2016-04-13;36(15):4362-76. 2016-04-13 [PMID: 27076431] (IHC-Fr, Mouse)
• Louise Thiry, Maxime Lemieux, Olivier D. Laflamme, Frédéric Bretzner Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits Journal of Neurophysiology 3/1/2016 [PMID: 26655819]
• Szilard Sajgo, Seid Ali, Octavian Popescu, Tudor Constantin Badea Dynamic expression of transcription factor Brn3b during mouse cranial nerve development Journal of Comparative Neurology 4/1/2016 [PMID: 26356988]
• Szilard Sajgo, Seid Ali, Octavian Popescu, Tudor Constantin Badea Dynamic expression of transcription factor Brn3b during mouse cranial nerve development Journal of Comparative Neurology 2016-04-01 [PMID: 26356988] (Immunohistochemistry, Mouse)
• Gay M, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol, 2015-04-11;13(0):24. 2015-04-11 [PMID: 25885041] (IHC, Mouse)
• Oliveira Fernandes M, Tourtellotte W Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis. J Neurosci, 2015-04-08;35(14):5566-78. 2015-04-08 [PMID: 25855173] (IHC-Fr, Mouse)
• Usoskin D, Furlan A, Islam S, Abdo H, Lonnerberg P, Lou D, Hjerling-Leffler J, Haeggstrom J, Kharchenko O, Kharchenko P, Linnarsson S, Ernfors P Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci, 2014-11-24;18(1):145-53. 2014-11-24 [PMID: 25420068] (IHC, Mouse)
• Romi E, Gokhman I, Wong E, Antonovsky N, Ludwig A, Sagi I, Saftig P, Tessier-Lavigne M, Yaron A ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A. Nat Commun, 2014-06-05;5(0):4058. 2014-06-05 [PMID: 24898499] (IHC, Mouse)
• Trolle , Carl, Konig , Niclas, Abrahamsson , Ninnie, Vasylovska , Svitlana, Kozlova , Elena N Boundary cap neural crest stem cells homotopically implanted to the injured dorsal root transitional zone give rise to different types of neurons and glia in adult rodents. BMC Neurosci, 2014-05-05;15(0):60. 5/5/2014 [PMID: 24884373]
• Gorokhova S, Gaillard S, Urien L, Malapert P, Legha W, Baronian G, Desvignes J, Alonso S, Moqrich A Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. PLoS Genet, 2014-02-06;10(2):e1004081. 2014-02-06 [PMID: 24516396] (IHC, Mouse)
• Saïda Hadjab, Marina C. M. Franck, Yiqiao Wang, Ulrich Sterzenbach, Anil Sharma, Patrik Ernfors et al. A Local Source of FGF Initiates Development of the Unmyelinated Lineage of Sensory Neurons The Journal of Neuroscience 11/6/2013 [PMID: 24198358]
• Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, Klein R Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci, 2013-03-20;33(12):5399-410. 2013-03-20 [PMID: 23516305] (IHC-Fr, Mouse)
• Hyung Jin Kim, Hae-Mi Woo, Jihee Ryu, Jinwoong Bok, Jin Woo Kim, Sang Back Choi et al. Conditional Deletion of Pten Leads to Defects in Nerve Innervation and Neuronal Survival in Inner Ear Development PLoS ONE 2/5/2013 [PMID: 23393595]
• Huan Liu, Michael Lu, Kathleen M. Guthrie Anterograde trafficking of neurotrophin-3 in the adult olfactory system in vivo Experimental Neurology 3/1/2013 [PMID: 23261763]
• Positional differences of axon growth rates between sensory neurons encoded by Runx3. EMBO J., 2012-08-17;31(18):3718-29. 2012-08-17 [PMID: 22903063] (IHC-Fr, Mouse)
• Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb. PLoS Biol., 2011-02-22;9(2):e1001020. 2011-02-22 [PMID: 21364975] (IHC, Mouse)
• Stephanie L. Courchesne, Maria F. Pazyra-Murphy, Daniel J. Lee, Rosalind A. Segal Neuromuscular Junction Defects in Mice with Mutation of dynein heavy chain 1 PLoS ONE 2/4/2011 [PMID: 21346813]
• Demel C, Hoegen T, Giese A Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis. J Neuroinflammation, 2011-01-24;8(1):7. 2011-01-24 [PMID: 21261959] (IHC-P, Mouse)
• Vaegter CB, Jansen P, Fjorback AW Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat. Neurosci., 2010-11-21;14(1):54-61. 2010-11-21 [PMID: 21102451] (IHC-Fr, Mouse)
• Gaelle M. Lefevre, Sanjeevkumar R. Patel, Doyeob Kim, Lino Tessarollo, Gregory R. Dressler Altering a Histone H3K4 Methylation Pathway in Glomerular Podocytes Promotes a Chronic Disease Phenotype PLoS Genetics 10/28/2010 [PMID: 21060806]
• Bouzas-Rodriguez J, Cabrera JR, Delloye-Bourgeois C, Ichim G, Delcros JG, Raquin MA, Rousseau R, Combaret V, Benard J, Tauszig-Delamasure S, Mehlen P Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis. J. Clin. Invest., 2010-02-15;120(3):850-8. 2010-02-15 [PMID: 20160348] (Neutralization, Human)
• Senzaki K, Ozaki S, Yoshikawa M, Ito Y, Shiga T Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons. Mol. Cell. Neurosci., 2009-12-23;43(3):296-307. 2009-12-23 [PMID: 20034568] (IHC, Mouse)
• Kawamata T, Ninomiya T, Toriyabe M, Yamamoto J, Niiyama Y, Omote K, Namiki A Immunohistochemical analysis of acid-sensing ion channel 2 expression in rat dorsal root ganglion and effects of axotomy. Neuroscience, 2006-09-01;143(1):175-87. 2006-09-01 [PMID: 16949762] (IHC, Rat)
• Tamura S, Morikawa Y, Senba E TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Neuroscience, 2005-01-01;130(1):223-8. 2005-01-01 [PMID: 15561438] (ICC, Mouse)

Review for TrkC Antibody (AF1404) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Mouse.

reviewed by: Verified Customer IF Mouse 01/05/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 23516305
• Species: Mouse

Bioinformatics

• Gene Symbol: NTRK3
• Uniprot:
  • Q6VNS1()