Recombinant Human GDNF Protein

Recombinant human GDNF (Catalog # 212-GD) has a molecular weight (MW) of 27.5 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).

Recombinant Human GDNF (Catalog # 212-GD) induces SH-SY5Y human neuroblastoma cell proliferation in the presence of Recombinant Human GFRa-1 Fc Chimera (Catalog # 714-GR). The activity is approximately 9-fold greater than the top competitor's GDNF.

1 μg/lane of Recombinant Human GDNF was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 17 kDa and 34 kDa, respectively.

• Reactivity: Hu
• Applications: Binding Activity, Bioactivity

Recombinant Human GDNF Protein Summary

• Additional Information: Analyzed by SEC-MALS
• Details of Functionality: Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED₅₀ for this effect is 2‑12 ng/mL in the presence of Recombinant Human GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera (Catalog # 714‑GR). Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera (Catalog # 714-GR) at 1 µg/mL can bind Recombinant Human GDNF with an apparent K_d <1 nM.
• Source: Mouse myeloma cell line, NS0-derived human GDNF protein
  Arg109-Ile211
• Accession #: P39905
• N-terminal Sequence: Arg109
• Structure / Form: Disulfide-linked homodimer
• Protein/Peptide Type: Recombinant Proteins
• Gene: GDNF
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Binding Activity
  • Bioactivity
• Theoretical MW: 11.6 kDa (monomer).
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human GDNF Protein

• Astrocyte-derived trophic factor
• ATF
• ATF1
• ATF2
• GDNF
• glial cell derived neurotrophic factor
• glial cell line derived neurotrophic factor
• glial cell line-derived neurotrophic factor
• HFB1-GDNF
• HGDNF
• HSCR3

Background

Glial Cell Line-derived Neurotrophic Factor (GDNF) is a neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons.

Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-beta  superfamily. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. NS0 expressed mature human GDNF lacks 31 residues from the amino-terminus of the predicted sequence. This glycosylated recombinant mature human GDNF still contains the seven conserved Cys residues found in all members of the TGF-beta superfamily and is biologically active. The GDNF sequence contains two potential glycosylation sites and insect cell‑expressed recombinant rat GDNF proteins are glycosylated. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.

Publications for GDNF (212-GD)(176)

Publications using 212-GD

• HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective bioRxiv : the preprint server for biology, 2023;0(0):. 2023-01-01 [PMID: 36798313] (Bioassay, Human)
• GR Linares, Y Li, WH Chang, J Rubin-Sigl, S Mendonca, S Hong, Y Eoh, W Guo, YH Huang, J Chang, S Tu, N Dorjsuren, M Santana, ST Hung, J Yu, J Perez, M Chickering, TY Cheng, CC Huang, SJ Lee, HJ Deng, KT Bach, K Gray, V Subramanya, J Rosenfeld, SV Alworth, H Goodarzi, JK Ichida SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS Cell Stem Cell, 2023;30(2):171-187.e14. 2023-01-01 [PMID: 36736291] (Bioassay, Human)
• CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendra, L Peng, H Oguro, J Kanaujiya, J Zou, D Sebesta, G Pratt, E Cross, J Blockwick, P Buxton, L Kinner-Bib, C Medura, C Tompkins, S Hughes, M Santiana, F Faghri, MA Nalls, D Vitale, S Ballard, YA Qi, DM Ramos, KM Anderson, J Stadler, P Narayan, J Papademetr, L Reilly, MP Nelson, S Aggarwal, LU Rosen, P Kirwan, V Pisupati, SL Coon, SW Scholz, T Priebe, M Öttl, J Dong, M Meijer, LJM Janssen, VS Lourenco, R van der Ka, D Crusius, D Paquet, AC Raulin, G Bu, A Held, BJ Wainger, RMC Gabriele, JM Casey, S Wray, D Abu-Bonsra, CL Parish, MS Beccari, DW Cleveland, E Li, IVL Rose, M Kampmann, C Calatayud, P Verstreken, L Heinrich, MY Chen, B Schüle, D Dou, ELF Holzbaur, MC Zanellati, R Basundra, M Deshmukh, S Cohen, R Khanna, M Raman, ZS Nevin, M Matia, J Van Lent, V Timmerman, BR Conklin, K Johnson Ch, K Zhang, S Funes, DA Bosco, L Erlebach, M Welzer, D Kronenberg, G Lyu, E Arenas, E Coccia, L Sarrafha, T Ahfeldt, JC Marioni, WC Skarnes, MR Cookson, ME Ward, FT Merkle A reference human induced pluripotent stem cell line for large-scale collaborative studies Cell Stem Cell, 2022;29(12):1685-1702.e22. 2022-01-01 [PMID: 36459969] (Bioassay, Human)
• JR Herdy, L Traxler, RK Agarwal, L Karbacher, JCM Schlachetz, L Boehnke, D Zangwill, D Galasko, CK Glass, J Mertens, FH Gage Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer&#039;s disease Cell Stem Cell, 2022;29(12):1637-1652.e6. 2022-01-01 [PMID: 36459967] (Bioassay, Human)
• M Jones, A Cunningham, N Frank, D Sethi The monoculture of cord-blood-derived CD34+ cells by an automated, membrane-based dynamic perfusion system with a novel cytokine cocktail Stem Cell Reports, 2022;0(0):. 2022-01-01 [PMID: 36332632] (Bioassay, Human)
• G Kim, L Nakayama, JA Blum, T Akiyama, S Boeynaems, M Chakrabort, J Couthouis, E Tassoni-Ts, CM Rodriguez, MC Bassik, AD Gitler Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2 Cell Reports, 2022;41(4):111508. 2022-01-01 [PMID: 36288714] (Bioassay, Human)
• C Seah, MS Breen, T Rusielewic, HN Bader, C Xu, CJ Hunter, B McCarthy, PJM Deans, M Chattopadh, J Goldberg, F Desarnaud, I Makotkine, JD Flory, LM Bierer, M Staniskyte, NYSCF Glob, SA Noggle, LM Huckins, D Paull, KJ Brennand, R Yehuda Modeling gene � environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression Nature Neuroscience, 2022;25(11):1434-1445. 2022-01-01 [PMID: 36266471] (Bioassay, Human)
• T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro Nature Communications, 2022;13(1):5427. 2022-01-01 [PMID: 36109497] (Cell Culture, Mouse)
• L Mahoney-Sa, H Bouchaoui, I Boussaad, A Jonneaux, K Timmerman, O Berdeaux, S Ayton, R Krüger, JA Duce, D Devos, JC Devedjian Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition Cell Reports, 2022;40(8):111231. 2022-01-01 [PMID: 36001957] (Bioassay, Human)
• R Lieberman, LK Cortes, G Gao, H Park, B Wang, PL Jones, RB Hunter, JP Leonard, RH Barker Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease PLoS ONE, 2022;17(8):e0271360. 2022-01-01 [PMID: 35921286] (Bioassay, Human)
• K ?uczkowska, O Taryma-Le?, J Bi?kowski, KE Soko?owska, D Strapagiel, J Jarczak, E Paczkowska, B Machali?sk, TK Wojdacz Long-Term Treatment with Bortezomib Induces Specific Methylation Changes in Differentiated Neuronal Cells Cancers, 2022;14(14):. 2022-01-01 [PMID: 35884461] (Bioassay, Human)
• M Sawamura, K Imamura, R Hikawa, T Enami, A Nagahashi, H Yamakado, H Ichijo, T Fujisawa, H Yamashita, S Minamiyama, M Kaido, H Wada, M Urushitani, H Inoue, N Egawa, R Takahashi Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation Scientific Reports, 2022;12(1):12636. 2022-01-01 [PMID: 35879519] (Bioassay, Human)
• Y Chen, Q Yin, XY Cheng, JR Zhang, H Jin, K Li, CJ Mao, F Wang, HZ Bei, CF Liu G2019S LRRK2 Mutation Enhances MPP+-Induced Inflammation of Human Induced Pluripotent Stem Cells-Differentiated Dopaminergic Neurons Frontiers in Neuroscience, 2022;16(0):947927. 2022-01-01 [PMID: 35873822] (Bioassay, Human)
• MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells Oncogene, 2022;31(0):100852. 2022-01-01 [PMID: 35782608] (Bioassay, Human)
• MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1 PLoS ONE, 2022;17(7):e0269683. 2022-01-01 [PMID: 35776705] (Bioassay, Human)
• AK Holzer, I Suciu, C Karreman, T Goj, M Leist Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro International Journal of Molecular Sciences, 2022;23(7):. 2022-01-01 [PMID: 35409095] (Differentiation, Differentiation, Human)
• Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 0;23(6):e54041. [PMID: 35384245] (Bioassay, Human)
• JM Suárez-Riv, CJ Pastor-Mal, A Romero-Gon, D Gómez-Fern, S Povea-Cabe, M Álvarez-Có, I Villalón-G, M Talaverón-, A Suárez-Car, M Munuera-Ca, JA Sánchez-Al Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases Frontiers in Pharmacology, 2022;13(0):862085. 2022-01-01 [PMID: 35370630] (Bioassay, Human)
• M Häkli, S Jäntti, T Joki, L Sukki, K Tornberg, K Aalto-Setä, P Kallio, M Pekkanen-M, S Narkilahti Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip International Journal of Molecular Sciences, 2022;23(6):. 2022-01-01 [PMID: 35328569] (Bioassay, Human)
• L Torres-Gar, JM P Domingue, E Brandi, C Haikal, JM Mudannayak, IC Brás, E Gerhardt, W Li, A Svanbergss, TF Outeiro, GK Gouras, JY Li Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation Scientific Reports, 2022;12(1):2987. 2022-01-01 [PMID: 35194057] (Bioassay, Human)
• N Moriarty, CW Gantner, CPJ Hunt, CM Ermine, S Frausin, S Viventi, DA Ovchinniko, D Kirik, CL Parish, LH Thompson A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells Cell Stem Cell, 2022;29(3):434-448.e5. 2022-01-01 [PMID: 35180398] (Bioassay, Human)
• WM Seo, J Yoon, JH Lee, Y Lee, H Lee, D Geum, W Sun, MR Song Modeling axonal regeneration by changing cytoskeletal dynamics in stem cell-derived motor nerve organoids Scientific Reports, 2022;12(1):2082. 2022-01-01 [PMID: 35136073] (Bioassay, Human)
• R Mzezewa, J Lotila, H Kiiski, A Vinogradov, FE Kapucu, J Peltola, S Hagman, S Narkilahti A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity Stem Cell Research, 2022;60(0):102665. 2022-01-01 [PMID: 35091307] (Bioassay, Human)
• P Nouri, A Zimmer, S Brüggemann, R Friedrich, R Kühn, N Prakash Generation of a NES-mScarlet Red Fluorescent Reporter Human iPSC Line for Live Cell Imaging and Flow Cytometric Analysis and Sorting Using CRISPR-Cas9-Mediated Gene Editing Cells, 2022;11(2):. 2022-01-01 [PMID: 35053384] (Bioassay, Human)
• A Bruzelius, S Kidnapilla, J Drouin-Oue, T Stoker, RA Barker, D Rylander O Reprogramming Human Adult Fibroblasts into GABAergic Interneurons Cells, 2021;10(12):. 2021-01-01 [PMID: 34943958] (Bioassay, Human)
• D Segelcke, HK Fischer, M Hütte, S Dennerlein, F Benseler, N Brose, EM Pogatzki-Z, M Schmidt Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice Cell Reports, 2021;37(12):110152. 2021-01-01 [PMID: 34936870] (Bioassay, Mouse)
• C Vajhøj, B Schmid, A Alik, R Melki, K Fog, B Holst, TC Stummann Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T alpha-synuclein levels and aggregation PLoS ONE, 2021;16(12):e0261536. 2021-01-01 [PMID: 34932569] (Bioassay, Human)
• AM Earley, LF Burbulla, D Krainc, R Awatramani Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons Scientific Reports, 2021;11(1):22257. 2021-01-01 [PMID: 34782629] (Bioassay, Human)
• P Sabatier, CM Beusch, AA Saei, M Aoun, N Moruzzi, A Coelho, N Leijten, M Nordenskjö, P Micke, D Maltseva, AG Tonevitsky, V Millischer, J Carlos Vil, S Kadekar, M Gaetani, K Altynbekov, A Kel, PO Berggren, O Simonson, KH Grinnemo, R Holmdahl, S Rodin, RA Zubarev An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation Nature Communications, 2021;12(1):6558. 2021-01-01 [PMID: 34772928] (Bioassay, Human)
• Y Sonobe, J Aburas, G Krishnan, AC Fleming, G Ghadge, P Islam, EC Warren, Y Gu, MW Kankel, AEX Brown, E Kiskinis, TF Gendron, FB Gao, RP Roos, P Kratsios A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation Nature Communications, 2021;12(1):6025. 2021-01-01 [PMID: 34654821] (Bioassay, Human)
• X Reed, MM Cobb, G Skinbinski, D Roosen, A Kaganovich, J Ding, S Finkbeiner, MR Cookson Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched Stem Cell Research, 2021;56(0):102558. 2021-01-01 [PMID: 34626895] (Cell Culture, Human)
• M Shibata, K Pattabiram, B Lorente-Ga, D Andrijevic, SK Kim, N Kaur, SK Muchnik, X Xing, G Santpere, AMM Sousa, N Sestan Regulation of prefrontal patterning and connectivity by retinoic acid Nature, 2021;0(0):. 2021-01-01 [PMID: 34599305] (Cell Culture, Human)
• Q Tang, P Gao, T Arzberger, M Höllerhage, J Herms, G Höglinger, T Koeglsperg Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion Cell Death & Disease, 2021;12(10):854. 2021-01-01 [PMID: 34535638] (Bioassay, Human)
• N Gustavsson, E Savchenko, O Klementiev, L Roybon The intracellular milieu of Parkinson&#039;s disease patient brain cells modulates alpha-synuclein protein aggregation Acta neuropathologica communications, 2021;9(1):153. 2021-01-01 [PMID: 34530929] (Bioassay, Human)
• K Tan, HW Song, MF Wilkinson RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade Cell Reports, 2021;36(3):109423. 2021-01-01 [PMID: 34289349] (Bioassay, Human)
• B Calamini, N Geyer, N Huss-Braun, A Bernhardt, V Harsany, P Rival, M Cindhuchao, D Hoffmann, S Gratzer Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson&#039;s disease Disease Models & Mechanisms, 2021;14(6):. 2021-01-01 [PMID: 34114604] (Bioassay, Human)
• IR de Luzy, KCL Law, N Moriarty, CPJ Hunt, JC Durnall, LH Thompson, A Nagy, CL Parish Human stem cells harboring a suicide gene improve the�safety and standardisation of neural transplants in Parkinsonian rats Nature Communications, 2021;12(1):3275. 2021-01-01 [PMID: 34045451] (Bioassay, Human)
• ZT Olmsted, JL Paluh Co-development of central and peripheral neurons with trunk mesendoderm in human elongating multi-lineage organized gastruloids Nature Communications, 2021;12(1):3020. 2021-01-01 [PMID: 34021144] (Bioassay, Human)
• A Boyer, X Zhang, A Levasseur, N Abou Nader, G St-Jean, MC Nagano, D Boerboom Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice PLoS ONE, 2021;16(5):e0251911. 2021-01-01 [PMID: 34015032] (Bioassay, Transgenic Mouse)
• G Pintacuda, FH Lassen, YH Hsu, A Kim, JM Martín, E Malolepsza, JK Lim, N Fornelos, KC Eggan, K Lage Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data Nature Communications, 2021;12(1):2580. 2021-01-01 [PMID: 33972534] (Bioassay, Human)
• B Calamini, N Geyer, N Huss-Braun, A Bernhardt, V Harsany, P Rival, M Cindhuchao, D Hoffmann, S Gratzer Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2 driven parkinson&#039;s disease Disease Models & Mechanisms, 2021;0(0):. 2021-01-01 [PMID: 33955449] (Bioassay, Human)
• J Mertens, JR Herdy, L Traxler, ST Schafer, JCM Schlachetz, L Böhnke, DA Reid, H Lee, D Zangwill, DP Fernandes, RK Agarwal, R Lucciola, L Zhou-Yang, L Karbacher, F Edenhofer, S Stern, S Horvath, ACM Paquola, CK Glass, SH Yuan, M Ku, A Szücs, LSB Goldstein, D Galasko, FH Gage Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer&#039;s patients Cell Stem Cell, 2021;0(0):. 2021-01-01 [PMID: 33910058] (Bioassay, Human)
• X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment Cell Reports, 2021;34(9):108802. 2021-01-01 [PMID: 33657377] (Bioassay, Human)
• B Sun, X Yang, F Hou, X Yu, Q Wang, HS Oh, P Raja, JM Pesola, EAH Vanni, S McCarron, J Morris-Lov, AHM Ng, GM Church, DM Knipe, DM Coen, D Pan Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency Nature Microbiology, 2021;0(0):. 2021-01-01 [PMID: 33558653] (Bioassay, Mouse)
• TY Feng, Q Li, F Ren, HM Xi, DL Lv, Y Li, JH Hu Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway Oxidative Medicine and Cellular Longevity, 2020;2020(0):5954635. 2020-01-01 [PMID: 33488926] (Bioassay, Goat)
• A Merlevede, EM Legault, V Drugge, RA Barker, J Drouin-Oue, V Olariu A quantitative model of cellular decision making in direct neuronal reprogramming Scientific Reports, 2021;11(1):1514. 2021-01-01 [PMID: 33452356] (Bioassay, Human)
• SE Howden, SB Wilson, E Groenewege, L Starks, TA Forbes, KS Tan, JM Vanslambro, EM Holloway, YH Chen, S Jain, JR Spence, MH Little Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk Cell Stem Cell, 2020;0(0):. 2020-01-01 [PMID: 33378647] (Bioassay, Transgenic Human)
• L Honkamäki, T Joki, NA Grigoryev, K Levon, L Ylä-Outine, S Narkilahti Novel method to produce a layered 3D scaffold for human pluripotent stem cell-derived neuronal cells Journal of neuroscience methods, 2020;350(0):109043. 2020-01-01 [PMID: 33345946] (Human)
• K Uchimura, H Wu, Y Yoshimura, BD Humphreys Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling Cell Reports, 2020;33(11):108514. 2020-01-01 [PMID: 33326782] (Bioassay, Human)
• D Jutzi, S Campagne, R Schmidt, S Reber, J Mechtershe, F Gypas, C Schweingru, M Colombo, C von Schroe, FE Loughlin, A Devoy, E Hedlund, M Zavolan, FH Allain, MD Ruepp Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis Nature Communications, 2020;11(1):6341. 2020-01-01 [PMID: 33311468] (Bioassay, Human)
• S Lito, A Sidibe, S Ilmjarv, P Burda, M Baumgartne, B Wehrle-Hal, KH Krause, A Marteyn Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors Cells, 2020;9(12):. 2020-01-01 [PMID: 33287330] (Bioassay, Human)
• J Giacomoni, A Bruzelius, CA Stamouli, D Rylander O Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons Cells, 2020;9(11):. 2020-01-01 [PMID: 33182669] (Bioassay, Human)
• N Ramesh, EL Daley, AM Gleixner, JR Mann, S Kour, D Mawrie, EN Anderson, J Kofler, CJ Donnelly, E Kiskinis, UB Pandey RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3 Acta Neuropathol Commun, 2020;8(1):177. 2020-01-01 [PMID: 33129345] (Cell Culture, Human)
• Y Kwon, Y Bang, SH Moon, A Kim, HJ Choi Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells Cell Death Dis, 2020;11(10):874. 2020-01-01 [PMID: 33070168] (Bioassay, Human)
• S Nolbrant, J Giacomoni, DB Hoban, A Bruzelius, M Birtele, D Chandler-M, M Pereira, DR Ottosson, SA Goldman, M Parmar Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons Stem Cell Reports, 2020;0(0):. 2020-01-01 [PMID: 32976765] (Bioassay, Human)
• JW Kim, X Yin, A Jhaldiyal, MR Khan, I Martin, Z Xie, T Perez-Rose, M Kumar, L Abalde-Atr, J Xu, L Chen, SM Eacker, DJ Surmeier, NT Ingolia, TM Dawson, VL Dawson Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis Cell Stem Cell, 2020;27(4):633-645.e7. 2020-01-01 [PMID: 32846140] (Bioassay, Human)
• KM Prautsch, A Schmidt, V Paradiso, DJ Schaefer, R Guzman, DF Kalbermatt, S Madduri Modulation of Human Adipose Stem Cells&#039; Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro Cells, 2020;9(9):. 2020-01-01 [PMID: 32839392] (Bioassay, Cell Culture, Human)
• K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates Sci Rep, 2020;10(1):14047. 2020-01-01 [PMID: 32820178] (Bioassay, Human)
• CA Tristan, P Ormanoglu, J Slamecka, C Malley, PH Chu, VM Jovanovic, Y Gedik, C Bonney, E Barnaeva, J Braisted, SK Mallanna, D Dorjsuren, MJ Iannotti, TC Voss, S Michael, A Simeonov, I Singeç Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells bioRxiv, 2020;0(0):. 2020-01-01 [PMID: 32793899] (Bioassay, Human)
• LS VandenBosc, SG Wohl, MS Wilken, M Hooper, C Finkbeiner, K Cox, L Chipman, TA Reh Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in M�ller Glial regenerative potential Sci Rep, 2020;10(1):13615. 2020-01-01 [PMID: 32788677] (Bioassay, Mouse)
• SI Mae, M Ryosaka, S Sakamoto, K Matsuse, A Nozaki, M Igami, R Kabai, A Watanabe, K Osafune Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential Cell Rep, 2020;32(4):107963. 2020-01-01 [PMID: 32726627] (Bioassay, Human)
• N Michel, P Narayanan, O Shomroni, M Schmidt Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction Cell Rep, 2020;32(3):107912. 2020-01-01 [PMID: 32697985] (Bioassay, Mouse)
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• Doers , Matthew, Musser , Michael, Nichol , Robert, Berndt , Erich R, Baker , Mei, Gomez , Timothy, Zhang , Su-Chun, Abbeduto , Leonard, Bhattacharyya , Anita iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth. Stem Cells Dev, 2014;23(15):1777-87. 2014-01-01 [PMID: 24654675] (Bioassay, Human)
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• Hasegawa K, Namekawa S, Saga Y MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells. Stem Cells, 2013;31(11):2517-27. 2013-01-01 [PMID: 23897718] (Cell Culture, Mouse)
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• Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori M, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain, 2013;6(0):19. 2013-01-01 [PMID: 23639079] (Bioassay, Human)
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Bioinformatics

• Gene Symbol: GDNF
• Uniprot:
  • P39905()