BDNF Products

Antibodies
BDNF Antibody (35928) [Unconj ...
BDNF Antibody (35928) [Unconjugated]
MAB248
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
BDNF Antibody (37129) [Unconj ...
BDNF Antibody (37129) [Unconjugated]
MAB848
Species: Hu
Applications: ELISA(Cap)
Host: Mouse Monoclonal
Antibody Pairs
BDNF Antibody Pair
BDNF Antibody Pair
H00000627-PW1
Species: Hu
Applications: WB, IP
ELISA Kits
BDNF ELISA Kit [Biotin]
BDNF ELISA Kit [Biotin]
KA0330
Species: Rt
BDNF ELISA Kit [Biotin]
BDNF ELISA Kit [Biotin]
KA0331
Species: Mu
BDNF ELISA Kit [Biotin]
BDNF ELISA Kit [Biotin]
KA0329
Species: Hu
Lysates
BDNF Overexpression Lysate (N ...
BDNF Overexpression Lysate (Native)
NBL1-07961
Applications: WB
BDNF Overexpression Lysate (D ...
BDNF Overexpression Lysate (Denatu...
H00000627-T02
Species: Hu
Applications: WB
BDNF Overexpression Lysate (D ...
BDNF Overexpression Lysate (Denatu...
H00000627-T01
Species: Hu
Applications: WB
Proteins
BDNF Recombinant Protein
BDNF Recombinant Protein
NBP2-52006
Species: Hu
Applications: PAGE
BDNF Recombinant Protein
BDNF Recombinant Protein
H00000627-P01
Species: Hu
Applications: WB, ELISA, PA
BDNF Recombinant Protein
BDNF Recombinant Protein
P3595
Species: Hu
Applications: Func, PAGE
RNAi
BDNF RNAi
BDNF RNAi
H00000627-R03
Species: Hu
BDNF RNAi
BDNF RNAi
H00000627-R06
Species: Hu
BDNF RNAi
BDNF RNAi
H00000627-R04
Species: Hu

Description

FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family. BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
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Human
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Product By Gene ID 627
Alternate Names
  • Abrineurin
  • neurotrophin
  • abrineurin
  • MGC34632
  • brain-derived neurotrophic factor

Research Areas for BDNF

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Immunology
Neuroscience

Bioinformatics Tool for BDNF

Discover related pathways, diseases and genes to BDNF. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related BDNF Blog Posts

Check out the latest blog posts on BDNF.
The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...    Read more.
Niemann Pick-C1 and cholesterol dynamics
Niemann-Pick type C1 (NPC1) mediates low-density cholesterol transport from late endosomes and lysosomes to other areas of the cell via receptor mediation endocytosis.  Although cholesterol moves freely inside the cell, it cannot independently expo...    Read more.
Synapsin I: Implicated in synaptic activity across a diverse range of studies
Synapsins are a family of neuronal proteins that are most renowned for their activity in modulating the pre-synaptic terminal.  Synapsin’s behavior is regulated by protein kinases and phosphatases, which alter the way that synapsin’s i...    Read more.
TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...    Read more.
TrkB and Nervous System Function
Neutrophins and their receptors play an important role in regulating the development of both the central and peripheral nervous systems. Neurotrophin ligand binding to each of their respective Trk cellular receptors is essential for the growth and sur...    Read more.
TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...    Read more.
BDNF Antibodies Aid Research on Alzheimer's Therapies
Brain-derived neurotrophic factor (BDNF) is known to be important for neuronal differentiation, survival, migration and plasticity in both the developing embryo and adult synapses. The BDNF antibody is also proving to be an important tool in Alzheimer...    Read more.
BDNF Antibodies and Synaptic Research
Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophins. During development it regulates the survival and differentiation of neuronal cell populations in the central and peripheral nervous system, while in adult synapse...    Read more.
Save Time & Money with High Quality Sandwich ELISA Kits
Enzyme-linked immunosorbent assay (ELISA) is a widely used technique for detecting concentration of proteins, using enzyme tagged antibodies with which react with dyes to produce a colorimetric or fluorescent signal. Sandwich ELISA takes this one step...    Read more.
Read more BDNF related blogs.