Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophins. During development it regulates the survival and differentiation of neuronal cell populations in the central and peripheral nervous system, while in adult synapses it is a major regulator of development, plasticity and transmission. We at Novus Biologicals are a leading antibody supplier for neurological research, with an extensive range of BDNF antibodies.
BDNF, like NGF, is a non-covalently linked homodimer, with an identical amino acid sequence in all known mature mammals. It is expressed at high levels in the hippocampus, cerebellum, placenta and fetal eye, and to a lesser extent in the pituitary gland, lung, spinal cord and skeletal and cardiac muscle.
BDNF plays an important role in adaptive neuronal responses, including long-term potentiation and depression, and short-term synaptic plasticity. It also plays a role in homeostasis, regulating intrinsic neuronal excitability. BDNF expression may be altered by such things as stress, seizures, ischemia and hypoglycemia. Modified BDNF expression has been linked to neuropathological disorders such as depression, Alzheimer's, epilepsy and Parkinson's disease.
Recent BDNF antibody studies have concentrated on activity-dependent changes (ADCs) to BDNF expression following synaptic transmission. ADCs are dependent on calcium influx, which induces transcription factors to bind nuclear calcium-response elements (CaREs).
In 2008, BDNF antibody research by Hong, et al. showed that activity-dependent BDNF expression was linked to CaRE expression and synaptic plasticity [PMID: 19038219]. In 2009, Kuczewski, et al. suggested BDNF functions as a target-derived messenger for activity-dependent synaptic plasticity [PMID: 19704877]. These experiments were dependent on products of the highest quality, supplied by leading antibody suppliers like Novus Biologicals.
Novus Biologicals offers many BDNF reagents for your research needs including: