PABPC4 Antibody

Images

 
Western Blot: PABPC4 Antibody [NB100-74594] - Detection of Human and Mouse PABP4 on HeLa whole cell lysate using NB100-74594. PABP4 was also immunoprecipitated by rabbit anti-PABP4 antibody NB100-74593.
Immunohistochemistry: PABPC4 Antibody [NB100-74594] - Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti- PABP4 used at a dilution of 1:200 (1ug/ml). Detection: DAB

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC-P, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.2 mg/ml
 

Independent Antibodies

 

Biological Strategies

     

Order Details

PABPC4 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 594 and 644 of human Poly(A)-binding protein 4 using the numbering given in entry NP_003810.1 (GeneID 8761).
Localization
Cytoplasmic
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PABPC4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunohistochemistry-Paraffin 1:100-1:500
  • Immunoprecipitation 2-5 ug/mg
Application Notes
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.
Publications
Read Publications using
NB100-74594 in the following applications:

  • IP
    1 publication
  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PABPC4 Antibody

  • APP1FLJ43938
  • APP-1PABP-4
  • Inducible poly(A)-binding protein
  • IPABP
  • iPABPpoly(A)-binding protein, cytoplasmic 4 (inducible form)
  • PABP4Activated-platelet protein 1
  • poly(A) binding protein, cytoplasmic 4 (inducible form)
  • Poly(A)-binding protein 4
  • polyadenylate-binding protein 4

Background

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PABPC4 Antibody (NB100-74594)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IP, WB.


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IP
(1)
WB
(1)
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Filter By Species
Human
(2)
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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PABPC4
Entrez
Uniprot