mGluR4 Antibody

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Immunohistochemistry-Paraffin: mGluR4 Antibody [NLS4713] - Anti-MGLUR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ...read more
Immunohistochemistry-Paraffin: mGluR4 Antibody [NLS4713] - Analysis of anti-MGLUR4 antibody with human brain, cortex, neurons at dilution 19 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Po, Mk, Pm, Rb, Rt, Ca, HaSpecies Glossary
Applications WB, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

mGluR4 Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from C-terminus of human GRM4 / MGLUR4.
Specificity
Human GRM4 / MGLUR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Rat (94%), Hamster (94%), Canine (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRM4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000 - 1:10000
  • Immunohistochemistry-Paraffin 19 ug/ml

Reactivity Notes

Chimpanzee, Gorilla, Gibbon, Equine (88%), Opossum (88%), Turkey (81%), Chicken (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for mGluR4 Antibody

  • glutamate receptor, metabotropic 4
  • GPRC1D
  • GPRC1Dmetabotropic glutamate receptor 4
  • GRM4
  • MGC177594
  • mGlu4
  • mGluR4
  • MGLUR4glutamate metabotropic receptor 4

Background

The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors that are linked to the inhibition of the cyclic AMP signaling cascade. Two protein isoforms have been reported in rat (mGluR4a 912 aa; mGluRb 983 aa), which differ at the C-terminus. GRM4 has been reported in various regions of the brain, eye, and spinal cord. ESTs have been isolated from brain, embryo, melanocyte/uterus/fetal heart, nerve, and testis libraries. Caution: GLUR4 refers to Ionotropic Glutamate Receptor 4, not to Metabotropic Glutamate Receptor 4 (mGLUR4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GRM4
Entrez