mGluR6 Antibody


Western Blot: metabotropic Glutamate Receptor 6 Antibody [NB300-189] - Detection of metabotropic Glutamate Receptor 6 in mouse brain lysate at 0.5 ug/ml.
Immunocytochemistry/ Immunofluorescence: metabotropic Glutamate Receptor 6 Antibody [NB300-189] - Detection of metabotropic Glutamate Receptor 6 in trapezoid body in mouse brain using NB300-189 and anti-rabbit Cy3 more

Product Details

Reactivity Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC-Fr
1 mg/ml

mGluR6 Antibody Summary

C-terminus of rat metabotropic Glutamate Receptor 6 [UniProt# P35349]
Integral membrane protein.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
0.1% BSA, Tris-glycine
0.1% Sodium Azide
1 mg/ml
Immunogen affinity purified


Application Notes
This metabotropic Glutamate Receptor 6 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen at ~96 kDa. Neurons of expected brain regions stain well.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
96 kDa
Control Peptide
mGluR6 Peptide (NB300-189PEP)
Read Publications using
NB300-189 in the following applications:

Reactivity Notes

Mouse and rat. Reactivity has been poor on human brain tissue.

Alternate Names for mGluR6 Antibody

  • CSNB1B
  • glutamate receptor, metabotropic 6
  • Gm3
  • GPRC1F
  • GPRC1Fmetabotropic glutamate receptor 6
  • GRM6
  • mGlu6
  • mGluR6
  • MGLUR6DKFZp686H1993


Metabotropic Glutamate Receptor 6 (Mglur6 or Grm6), member of class III of Mglur family/GPCR3 family, is a multi-pass membrane protein localized in cell membrane with restricted expression in retinal inner nuclear layer on dendrites of ON-bipolar cells wherein it interact with effector G protein G0 alpha and act as a receptor for glutamate. An increment of light intensity in retina hyperpolarizes the photoreceptor to set off two opposing signals in OFF and ON bipolar cells, whereas in darkness, glutamate released by photoreceptors depolarizes OFF bipolar cells with hyperpolarization of ON bipolar cells. This ON bipolar cell "sign inverting" cascade involves glutamate mediated activation of Mglur6 leading to G0 alpha stimulation which results in closure of a presumably constitutively active nonselective cation channel TRPM1 (transient receptor potential melastatin 1). mGluR6 activity is mediated by a G-protein that inhibits adenylate cyclase activity and mGluR6 is the only known mGluR that mediates direct synaptic transmission in the nervous system with its role in mediating ON-response in vertebrate retinal ON-pathway. Genetic inactivation of mGluR6 in murine model blocks the ON-response and in humans, mutations in the mGluR6 gene have been linked to congenital stationary night blindness, characterized in the electroretinogram by the absence of an ON response.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: Flow, IHC
Species: Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr
Species: Hu, Mu, Rt, Ch
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Mu
Applications: WB, ICC/IF
Species: Hu
Applications: IHC, IHC-P
Species: Hu, Mu, Rt, Bv, Ca, Eq, Mk, Pm
Applications: WB, IHC-P
Species: Hu
Applications: WB, IHC
Species: Hu
Applications: WB, IHC
Species: Hu
Applications: WB, ICFlow
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Species: Hu
Applications: WB, IHC, IHC-P, PEP-ELISA
Species: Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu
Applications: Flow, ICC/IF, IHC-Fr
Species: Hu, Mu
Applications: WB, DB, IHC, IHC-P
Species: Hu, Mu, Rt, Ch, Pm, Ze
Applications: WB
Species: Hu, Mu, Rt
Applications: WB
Species: Mu, Rt
Applications: WB, ICC/IF, IHC-Fr

Publications for mGluR6 Antibody (NB300-189)(3)

Reviews for mGluR6 Antibody (NB300-189) (0)

There are no reviews for mGluR6 Antibody (NB300-189). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for mGluR6 Antibody (NB300-189) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Other Available Formats

Additional mGluR6 Antibody Products

Related Products by Gene

Bioinformatics Tool for mGluR6 Antibody (NB300-189)

Discover related pathways, diseases and genes to mGluR6 Antibody (NB300-189). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for mGluR6 Antibody (NB300-189)

Discover more about diseases related to mGluR6 Antibody (NB300-189).

Pathways for mGluR6 Antibody (NB300-189)

View related products by pathway.

PTMs for mGluR6 Antibody (NB300-189)

Learn more about PTMs related to mGluR6 Antibody (NB300-189).

Research Areas for mGluR6 Antibody (NB300-189)

Find related products by research area.

Blogs on mGluR6

There are no specific blogs for mGluR6, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol GRM6

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NB300-189 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought