Applications: Flow, IHC, CyTOF-ready
Host: Sheep Polyclonal
Species: Hu, Mu, Rt, Po, Mk, Pm, Rb, Ca, Ha
Applications: WB, IHC-P
Host: Rabbit Polyclonal
Applications: RNAi, RNAi SP
The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors that are linked to the inhibition of the cyclic AMP signaling cascade. Two protein isoforms have been reported in rat (mGluR4a 912 aa; mGluRb 983 aa), which differ at the C-terminus. GRM4 has been reported in various regions of the brain, eye, and spinal cord. ESTs have been isolated from brain, embryo, melanocyte/uterus/fetal heart, nerve, and testis libraries. Caution: GLUR4 refers to Ionotropic Glutamate Receptor 4, not to Metabotropic Glutamate Receptor 4 (mGLUR4).
|Product By Gene ID
- GPRC1Dmetabotropic glutamate receptor 4
- MGLUR4glutamate metabotropic receptor 4
- glutamate receptor, metabotropic 4
Bioinformatics Tool for mGluR4
Discover related pathways, diseases and genes to mGluR4. Need help? Read the Bioinformatics Tool Guide
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