mGluR4 Products

Description

L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Bioinformatics

Entrez	2914 Human 268934 Mouse 24417 Rat
Product By Gene ID	2914
Alternate Names	glutamate receptor, metabotropic 4 GPRC1D GPRC1Dmetabotropic glutamate receptor 4 GRM4 MGC177594 mGlu4 mGluR4 MGLUR4glutamate metabotropic receptor 4

Research Areas for mGluR4

Find related products by research area and learn more about each of the different research areas below.

GPCR
Neuronal Cell Markers
Neuroscience
Neurotransmission
Vision