mGluR7 Antibody

Images

 
Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS921] - Anti-GRM7 / MGLUR7 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen ...read more
Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS921] - Analysis of anti-mGluR7 antibody with human brain, neurons and glia.
Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS921] - Analysis of anti-MGLUR7 antibody with human adrenal.
Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS921] - Anti-GRM7 / MGLUR7 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS921] - Brain, Hypothalamus
Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS921] - Eye, Retina

Product Details

Summary
Reactivity Hu, Bv, Mu, Rt, Ca, Pm, Eq, Pm, Pm-OrSpecies Glossary
Applications WB, IHC, IHC-P, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

mGluR7 Antibody Summary

Immunogen
Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GRM7 / MGLUR7.
Localization
Cell membrane; Multi-pass membrane protein.
Specificity
Human mGluR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM8 (63%).
Predicted Species
Mouse (95%), Rat (95%), Canine (95%), Equine (95%), Monkey (95%), Orangutan (95%), Chimpanzee (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRM7
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100 - 1:2000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 6 - 16 ug/ml
  • Immunocytochemistry 1:10 - 1:500

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (95%), Marmoset (95%), Gibbon (89%), Rabbit (89%), Opossum (89%), Chicken (84%), Xenopus (84%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for mGluR7 Antibody

  • FLJ40498
  • glutamate receptor, metabotropic 7
  • GPRC1G
  • GRM7
  • metabotropic glutamate receptor 7
  • MGLU7
  • mGluR7
  • MGLUR7GPRC1GGLUR7

Background

Metabotropic Glutamate Receptor GRM7 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. GRM7 is highly concentrated at presynaptic terminals and is thought to play an important role in the modulation of glutamatergic synaptic transmission by effecting presynaptic inhibition of glutamate release. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors, which are linked to inhibition of the cyclic AMP signaling cascade. Five mRNA variants of GRM7 have been described; most of the variants are expressed in brain and retina, although there are non-neuronal variants that may have different functional properties. GRM7 has been reported to be expressed in active zones of presynaptic axon terminals in various regions of the brain, eye, and spinal cord. Caution: GLUR7 refers to Ionotropic Glutamate Receptor 7, not to Metabotropic Glutamate Receptor 7 (mGLUR7).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GRM7
Entrez