mGluR2 Antibody

Images

 
Immunohistochemistry-Paraffin: mGluR2 Antibody [NLS892] - Analysis of anti-GRM2 / MGLUR2 antibody with human brain, glioblastoma.
Immunohistochemistry-Paraffin: mGluR2 Antibody [NLS892] - Analysis of anti-GRM2 / MGLUR2 antibody with brain, neuron.
Immunohistochemistry-Paraffin: mGluR2 Antibody [NLS892] - Analysis of anti-GRM2 / MGLUR2 antibody with transfection control.
Immunohistochemistry-Paraffin: mGluR2 Antibody [NLS892] - Analysis of anti-GRM2 / MGLUR2 antibody with transfected cells expressing metabotropic Glutamate Receptor 2 at 5 ug/ ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC-P, ICC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

mGluR2 Antibody Summary

Immunogen
Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GRM2 / MGLUR2.
Localization
Membrane; multi-pass membrane protein
Specificity
Human GRM2 / MGLUR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM3 (42%).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRM2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100 - 1:2000
  • Immunohistochemistry-Paraffin 5 - 10 ug/ml
  • Immunocytochemistry 1:10 - 1:500

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for mGluR2 Antibody

  • GLUR2
  • glutamate metabotropic receptor 2
  • glutamate receptor, metabotropic 2
  • GPRC1B
  • GPRC1Bmetabotropic glutamate receptor 2
  • GRM2
  • mGlu2
  • mGluR2
  • MGLUR2glutamate receptor homolog
  • mGluR7

Background

The Metabotropic Glutamate Receptor GRM2 binds L-glutamate and has been linked to the inhibition of the cyclic AMP signaling cascade. GRM2 is involved in mediating the suppression of neurotransmission and in synaptogenesis and synaptic stabilization. Glutamatergic neurotransmission plays a role in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. GRM2 has been reported in various regions of the human and animal brain, as well as in rat eye and spinal cord. ESTs have been isolated from brain and testis libraries. Caution: GLUR2 refers to Ionotropic Glutamate Receptor 2, not to Metabotropic Glutamate Receptor 2 (mGLUR2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GRM2
Entrez