This LPIN1 antibody is useful for Immunohistochemistry paraffin embedded sections and Western blot analysis, where a and is seen at ~97 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
97 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS and 30% Glycerol
0.1% Sodium Azide
Immunogen affinity purified
Alternate Names for Lipin 1 Antibody
KIAA0188phosphatidate phosphatase LPIN1
LPIN1 (phosphatidate phosphatase LPIN1) is expressed most abundantly in adipocytes and skeletal muscles wherein it play two major roles (i) in the cytoplasm, LPIN1 acts as a phosphatidate phosphatase 1 (PAP1) enzyme converting phosphatidic acid to diacylglycerol which is the precursor of both triglycerides and phospholipids (ii) in the nucleus, LPIN1 functions as a transcriptional co-activator through interaction with transcription factors which regulate the expression of genes involved in energy pathways. It can interact with MEF2C and LPIN1 interction with PPARA as well as PPARGC1A leads to a complex formation that modulates gene transcription. Three LPIN-1 protein isoforms are generated by alternative splicing, specifically involved in either PAP1 activity, transcriptional function or lipid droplets biogenesis. Defects in LPIN1 are a cause of autosomal recessive acute recurrent myoglobinuria (ARARM).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for Lipin 1 Antibody (NB110-57150). (Showing 1 - 1 of 1 FAQs).
I want to use Lpin1 antibody for mouse liver paraffin sections (tumor also). What is your opinion about success of this staining? What is the suitable dilution for IHC?
NB110-57150 has been tested and validated for use in human, mouse and rat. It is therefore guaranteed to work in those species and should be a good antibody to use in your mouse sections. The recommended dilution for IHC on paraffin embedded sections is 1:100 to 1:250.
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