LAMP-2/CD107b Antibody (H4B4) [Allophycocyanin]

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Product Details

Summary
Reactivity Hu, Mu, Rt(-)Species Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Clone
H4B4
Clonality
Monoclonal
Host
Mouse
Conjugate
Allophycocyanin

LAMP-2/CD107b Antibody (H4B4) [Allophycocyanin] Summary

Immunogen
Human adherent spleen cells.
Localization
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Marker
Late Endosome / Lysosome marker
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
LAMP2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/Immunofluorescence 1:10-1:100
  • Immunohistochemistry 1:100-1:200
  • Immunohistochemistry-Frozen 1:100-1:200
  • Immunohistochemistry-Paraffin 1:100-1:200
Application Notes
In Western blot, bands may be seen at ~40 kDa and 45 kDa representing the unglycosylated isoforms of LAMP2 and ~110 kDa representing the glycosylated form.

Reactivity Notes

Does not react with rat. Mouse reactivity reported in scientific literature (PMID: 27863209)

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LAMP-2/CD107b Antibody (H4B4) [Allophycocyanin]

  • CD107 antigen-like family member B
  • CD107b antigen
  • CD107b
  • LAMP2
  • LAMP-2
  • LAMPB
  • LGP110
  • lysosomal-associated membrane protein 2
  • lysosome-associated membrane glycoprotein 2
  • Lysosome-associated membrane protein 2

Background

LAMP2 (Lysosome-associate protein 2) is one of a family of membrane glycoproteins whose function is to provide selectins with carbohydrate ligands. LAMP2 has been implicated in tumor metastasis, as well as overall protection, maintenance and adhesion of the lysosome. Specifically, LAMP2 may protect the lysosomal membrane from auto digestion, and also maintain the acidic environment necessary for the lysosome to function correctly. On a subcellular level, LAMP2 is expressed as a single-pass type I membrane protein, shuttling between endosomes, lysosomes, and the plasma membrane. Mutations in LAMP2 lead to a lysosomal glycogen storage disease known as "Danon Disease". Recently, caspase activation has been suggested in the extracellular export of autophagic vesicles, such as LAMP2 (PMID: 22692030).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for LAMP-2/CD107b Antibody (NBP2-21799) (0)

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for LAMP-2/CD107b Antibody (NBP2-21799) (0)

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Secondary Antibodies

 

Isotype Controls

Additional LAMP-2/CD107b Products

Bioinformatics Tool for LAMP-2/CD107b Antibody (NBP2-21799)

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Diseases for LAMP-2/CD107b Antibody (NBP2-21799)

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Research Areas for LAMP-2/CD107b Antibody (NBP2-21799)

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Blogs on LAMP-2/CD107b.

LAMP2 - a marker of lysosomes and late endosomes
Lysosomes are membrane-bound organelles responsible for the degradation of various biological macromolecules. Vesicles containing hydrolytic enzymes bud from the Golgi and fuse with endosomes to form the mature lysosome capable of breaking down va...  Read full blog post.

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Bioinformatics

Gene Symbol LAMP2
Entrez