LAMP-2/CD107b Products

Antibodies
LAMP-2/CD107b Antibody
LAMP-2/CD107b Antibody
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
LAMP-2/CD107b Antibody (SA46- ...
LAMP-2/CD107b Antibody (SA46-01)
NBP2-67298
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Monoclonal
Lysates
LAMP-2/CD107b Overexpression ...
LAMP-2/CD107b Overexpression Lysate
NBP2-08128
Species: Hu
Applications: WB
Proteins
Recombinant Human LAMP-2/CD10 ...
Recombinant Human LAMP-2/CD107b Pr...
6228-LM
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse LAMP-2/CD10 ...
Recombinant Mouse LAMP-2/CD107b Pr...
NBP2-50563
Species: Mu
Applications: PAGE

Description

LAMP-2 (Lysosome-associated membrane protein 2) is a single-pass type I membrane protein that belongs to a family of membrane glycoproteins (~40 KDa). LAMP-2 protein is encoded by nine exons, with the first 8 exons and a portion of exon 9 encoding the highly glycosylated protein domains within the lysosomal lumen. The transmembrane and cytosolic carboxy-terminal domains of LAMP-2 are encoded by the remaining sequence of exon 9 and conform the receptor for targeting proteins to the lysosome. Splicing of exon 9 in the LAMP-2 pre mRNA leads to various splice forms with distinct cytosolic domains. Three splice variants, LAMP-2A, -2B and -2C, have been identified which shuttle between the plasma membrane, endosomal compartment and lysosomes (1). Tissue specific expression has been described for each LAMP-2 splice variant, with LAMP-2A being more ubiquitously expressed (e.g., placenta, lung, liver, pancreas and prostate), LAMP-2B predominantly expressed in skeletal muscle and LAMP-2C in brain tissue (1). All LAMP-2 splice variants participate in lysosomal degradation processes. LAMP-2A is the only variant that serves as a receptor targeting proteins for lysosomal degradation in chaperone-mediated autophagy (2,3). LAMP-2B is essential for macroautophagy in cardiomyocytes, where it facilitates autophagosome-lysosome fusion. LAMP-2B mutations underscore the myopathy and severe hypertrophic cardiomyopathy in Danon disease which results from deficits in autophagy (1, 4). Vasculopathy of coronary and cerebral arteries is a rare phenotype in Danon patients that is also associated with deficient autophagy processing of proteins and cellular organelles (5). LAMP2C serves as a receptor for DNA and RNA, facilitating their lysosomal degradation through DNA-autophagy and RNA-autophagy, respectively (1).

References

1. Rowland, T. J., Sweet, M. E., Mestroni, L., & Taylor, M. R. G. (2016). Danon disease - dysregulation of autophagy in a multisystem disorder with cardiomyopathy. Journal of Cell Science. https://doi.org/10.1242/jcs.184770

2. Alfaro, I. E., Albornoz, A., Molina, A., Moreno, J., Cordero, K., Criollo, A., & Budini, M. (2019). Chaperone mediated autophagy in the crosstalk of neurodegenerative diseases and metabolic disorders. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2018.00778

3. Schneider, J. L., & Cuervo, A. M. (2014). Autophagy and human disease: Emerging themes. Current Opinion in Genetics and Development. https://doi.org/10.1016/j.gde.2014.04.003

4. Chi, C., Leonard, A., Knight, W. E., Beussman, K. M., Zhao, Y., Cao, Y., Song, K. (2019). LAMP-2B regulates human cardiomyocyte function by mediating autophagosome lysosome fusion. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1808618116

5. Nguyen, H. T., Noguchi, S., Sugie, K., Matsuo, Y., Nguyen, C. T. H., Koito, H., Tsukaguchi, H. (2018). Small-Vessel Vasculopathy Due to Aberrant Autophagy in LAMP-2 Deficiency. Scientific Reports. https://doi.org/10.1038/s41598-018-21602-8

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 3920
Alternate Names
  • LGP-96
  • Lysosomal Associated Membrane Protein 2
  • CD107 antigen-like family member B
  • CD107b antigen
  • LAMP-2
  • lysosome-associated membrane glycoprotein 2
  • Lysosome-associated membrane protein 2
  • LGP110
  • CD107b
  • LAMPB
  • lysosomal-associated membrane protein 2

Research Areas for LAMP-2/CD107b

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Growth and Development
Lysosome Markers
Mast Cell Markers
Membrane Trafficking and Chaperones
Neuronal Cell Markers

PTMs for LAMP-2/CD107b

Learn more about PTMs related to LAMP-2/CD107b.

Cleavage
Phosphorylation
Glycosylation
Ubiquitination
Biotinylation
Oxidation
Dephosphorylation
Ribosylation

Bioinformatics Tool for LAMP-2/CD107b

Discover related pathways, diseases and genes to LAMP-2/CD107b. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related LAMP-2/CD107b Blog Posts

Check out the latest blog posts on LAMP-2/CD107b.
Chaperone Mediated Autophagy (CMA) does it all!
By Christina Towers, PhD. The degradation of cellular proteins is a critical step of both regulation and quality control and results in the turn over and recycling of critical amino acids. The two main mechanisms o...    Read more.
LAMP2 - a marker of lysosomes and late endosomes
Lysosomes are membrane-bound organelles responsible for the degradation of various biological macromolecules. Vesicles containing hydrolytic enzymes bud from the Golgi and fuse with endosomes to form the mature lysosome capable of breaking down va...    Read more.
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