Glypican 3 Antibody (1G12) [Janelia Fluor® 549]


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Product Details

Reactivity HuSpecies Glossary
Applications Flow, IHC, IHC-P, ICC/IF
Janelia Fluor 549

Order Details

Glypican 3 Antibody (1G12) [Janelia Fluor® 549] Summary

A recombinant fragment containing amino acids 511-580 of human glypican-3.
Hepatocellular Carcinoma Marker
Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm's tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm's tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.
IgG1 Kappa
Protein A or G purified
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  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Protein A or G purified


Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus

Alternate Names for Glypican 3 Antibody (1G12) [Janelia Fluor® 549]

  • DGSX
  • Glypican 3
  • glypican proteoglycan 3
  • glypican-3
  • GPC3
  • GTR2-2
  • heparan sulphate proteoglycan
  • Intestinal protein OCI-5
  • MXR7
  • OCI5
  • OCI-5
  • secreted glypican-3
  • SGB
  • SGBS


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47760AF350
Alexa Fluor 405 NBP2-47760AF405
Alexa Fluor 488 NBP2-47760AF488
Alexa Fluor 532 NBP2-47760AF532
Alexa Fluor 594 NBP2-47760AF594
Alexa Fluor 647 NBP2-47760AF647
Alexa Fluor 700 NBP2-47760AF700
Alexa Fluor 750 NBP2-47760AF750
Allophycocyanin NBP2-47760APC
Biotin NBP2-47760B
DyLight 350 NBP2-47760UV
DyLight 405 NBP2-47760V
DyLight 488 NBP2-47760G
DyLight 550 NBP2-47760R
DyLight 594 NBP2-47760DL594
DyLight 650 NBP2-47760C
DyLight 680 NBP2-47760FR
DyLight 755 NBP2-47760IR
FITC NBP2-47760F
HRP NBP2-47760H
Janelia Fluor 549 NBP2-47760JF549
Janelia Fluor 646 NBP2-47760JF646
PE NBP2-47760PE
PerCP NBP2-47760PCP

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Blogs on Glypican 3.

Glypican 3 as a biomarker for gastro-esophageal adenocarcinoma
By Jamshed Arslan, Pharm. D., PhD. Gastroesophageal adenocarcinoma originates from the glandular epithelium of the esophagus, gastroesophageal junction and stomach. The incidence of gastroesophageal adenocarcinoma is...  Read full blog post.

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Gene Symbol GPC3
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