Western Blot: Glutamine Synthetase Antibody [NB110-41404] - Analysis of glutamine synthase. 40ug of lysates from mouse (Lanes M), rat (Lanes R), pig (Lanes P), bovine (Lanes B), or human (Lanes Hu) retina were probed. A ...read more
Immunohistochemistry: Glutamine Synthetase Antibody [NB110-41404] - Localization of glutamine synthase in the retina. Paraffin sections of mouse (A, B), rat (C, D, G-I), or human (E, F) retina fixed in 4% ...read more
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
0.05% Sodium Azide
Alternate Names for Glutamine Synthetase Antibody
cell proliferation-inducing protein 59
glutamate-ammonia ligase (glutamine synthase)
proliferation-inducing protein 43
Glutamine synthetase (GLUL) is an enzyme responsible for the de novo synthesis of glutamine (from glutamate and ammonia, wherein glutamate act as nitrogen donor/acceptor) and for production of gamma-aminobutyric acid/GABA (4-aminobutanoate). GLUL is expressed in a wide variety of human cells, such as astrocytes (marker rotein), skeletal cells, adipocytes, hepatocytes and sperms. GLUL activity in vertebrate brain is generally high as it protects this ammonia-sensitive organ from harmful effects of ammonia and is involves in recycling of neurotransmitter glutamate also. GLUL is essential in maintaining cellular homeostasis and besides its involvement in ammonia detoxification, GLUL participates in maintaining amino acid/energy balance, cellular redox control, nucleotide biosynthesis and neurotransmitters regulation. Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) which is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for Glutamine Synthetase Antibody (NB110-41404). (Showing 1 - 1 of 1 FAQ).
I'm looking for a primary antibody specific to the cytosolic isoform of glutamine synthetase.
I see no evidence that glutamine synthetase has multiple isoforms. Please see this link to UniProt for more details. NB110-41404 should work just fine for you as the only known isoform appears to be cytoplasmic.
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