Glypican 3 Products

Description

The Glypican 3 (GPC3) gene encodes for a member of the glypican-related integral membrane proteoglycan family (GRIPS). Two isoforms of the protein exist, isoform 1 at a length of 580 amino acids long and 65 kDA while isoform 2 is 526 amino acids long at 59 kDA. The protein encoded by GPC3 is thought to prevent the dipeptidyl peptidase activity of DPP4 and may participate in the suppression and regulation of growth in the predominately mesodermal tissues and organs. The GPC3 gene participates in the Wnt signaling pathway, metabolism, and visual phototransduction through interactions with genes FGF2, WNT3A, WNT7B, BCAN, and BGN. GPC3 has been researched in various diseases such as paine syndrome, horner's sundrome, liver cirrhosis, simpson-golabi-behmel syndrome, germ cell tumors, wilms tumors, complex regional pain syndrome, and hepatocellulcar carcinoma.

Bioinformatics

Entrez	2719 Human
Uniprot	NP_004475 Human NP_004475.1 Human P51654 Human
Product By Gene ID	2719
Alternate Names	DGSX glypican 3 glypican proteoglycan 3 glypican-3 GTR2-2 heparan sulphate proteoglycan Intestinal protein OCI-5 MXR7 OCI5 OCI-5 secreted glypican-3 SGB SGBS SGBS1SDYS

Related Glypican 3 Blog Posts

Check out the latest blog posts on Glypican 3.

Glypican 3 as a biomarker for gastro-esophageal adenocarcinoma By Jamshed Arslan, Pharm. D., PhD. Gastroesophageal adenocarcinoma originates from the glandular epithelium of the esophagus, gastroesophageal junction and stomach. The incidence of gastroesophageal adenocarcinoma is ...    Read more.

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