GluR5/GRIK1 Antibody

Images

 
Western Blot: GluR5/GRIK1 Antibody [NBP1-76849] - P815 cell lysate with Glutamate receptor 5 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: GluR5/GRIK1 Antibody [NBP1-76849] - Staining of Grik1 in mouse brain tissue with Grik1 Antibodyat 20 ug/mL.
Immunohistochemistry: GluR5/GRIK1 Antibody [NBP1-76849] - Staining of Grik1 in mouse brain tissue with Grik1 Antibodyat 5 ug/mL.
Immunocytochemistry/ Immunofluorescence: GluR5/GRIK1 Antibody [NBP1-76849] - Immunofluorescence of Grik1 in Human Brain cells with Grik1 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: GluR5/GRIK1 Antibody [NBP1-76849] - Human brain tissue using Glutamate receptor 5 antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

GluR5/GRIK1 Antibody Summary

Immunogen
Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human Grik1. The immunogen is located within the last 50 amino acids of Grik1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRIK1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Control Peptide
GluR5/GRIK1 Peptide (NBP1-76849PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GluR5/GRIK1 Antibody

  • EAA3
  • EEA3
  • GLR5
  • GluK1
  • GluR5
  • GluR-5
  • glutamate receptor, ionotropic, kainate 1
  • GRIK1
  • ionotropic kainate 1

Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GRIK1
Entrez
Uniprot