KA2/GRIK5/Glutamate Receptor KA2 Antibody - BSA Free

Western Blot: KA2/GRIK5/Glutamate Receptor KA2 Antibody [NBP1-76853] - Human brain tissue lysate with Grik5 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.

Immunohistochemistry: KA2/GRIK5/Glutamate Receptor KA2 Antibody - BSA Free [NBP1-76853] - Immunohistochemical staining of human brain tissue using KA2/GRIK5/Glutamate Receptor KA2 antibody at 2.5 ug/mL.

Immunocytochemistry/ Immunofluorescence: KA2/GRIK5/Glutamate Receptor KA2 Antibody - BSA Free [NBP1-76853] - Immunofluorescence of KA2/GRIK5/Glutamate Receptor KA2 in Human Brain cells with KA2/GRIK5/Glutamate Receptor KA2 antibody at 20 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

KA2/GRIK5/Glutamate Receptor KA2 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit KA2/GRIK5/Glutamate Receptor KA2 Antibody - BSA Free (NBP1-76853) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. Anti-KA2/GRIK5/Glutamate Receptor KA2 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human Grik5. The immunogen is located within the last 50 amino acids of Grik5. Amino Acid Squence: EATSPPRPRPGPAGPRE
• Specificity: This Grik5 antibody does not cross-react with Grik4.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GRIK5
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/mL
  • Immunohistochemistry 2.5 ug/mL
  • Immunohistochemistry-Paraffin 2-5 ug/ml
  • Western Blot 0.5 - 2 ug/mL
• Control Peptide:

  KA2/GRIK5/Glutamate Receptor KA2 Peptide (NBP1-76853PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for KA2/GRIK5/Glutamate Receptor KA2 Antibody - BSA Free

• EAA2
• Excitatory amino acid receptor 2
• GluK5
• glutamate receptor KA2
• Glutamate receptor KA-2
• glutamate receptor, ionotropic kainate 5
• glutamate receptor, ionotropic, kainate 5
• GRIK2
• GRIK5
• KA2/GRIK5
• KA2GRIK2

Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface. This Grik5 antibody does not cross-react with Grik4.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for KA2/GRIK5/Glutamate Receptor KA2 Antibody (NBP1-76853)(1)

Publication using NBP1-76853

• Sareddy GR, Pratap UP, Venkata PP, et al. Activation of estrogen receptor beta signaling reduces stemness of glioma stem cells Stem cells (Dayton, Ohio) 2021-01-20 [PMID: 33470499]

Bioinformatics

• Gene Symbol: GRIK5
• Uniprot:
  • NP_002079()