DISC1 Antibody [DyLight 488]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 488

DISC1 Antibody [DyLight 488] Summary

Immunogen
A synthetic peptide made to an internal region (within residues 400-500) of the rat DISC1 protein. [Swiss-Prot# Q810H6]
Localization
DISC-1 localizes to the nucleus, whereas mutant DISC-1 localization occurs mainly in the cytoplasm. It co-localizes with the following organelle structure antibodies: PD1, calnexin, GIANTIN, 58K, Rab4, LAMP-1, RAP1, KDEL, and catalase.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DISC1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This DISC1 antibody is useful for Immunocytochemistry/Immunofluorescence and Immunohistochemistry paraffin embedded sections.Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 24560582) The theoretical molecular weight of DISC1 is ~90 kDa. Preliminary Western Blot studies have been performed with this antibody, where several non-specific bands are seen. Due to alternative splicing, DISC1 may also run at ~75 and 100 kDa. In ICC/IF, cytoplasmic staining was observed in PC12 cells.

Reactivity Notes

Human, rat and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for DISC1 Antibody [DyLight 488]

  • C1orf136
  • DISC1
  • disrupted in schizophrenia 1 protein
  • disrupted in schizophrenia 1
  • FLJ13381
  • FLJ21640
  • FLJ25311
  • FLJ41105
  • KIAA0457
  • SCZD9

Background

The 'Disrupted In Schizophrenia' gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2 an beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB110-40773AF350
Alexa Fluor 405 NB110-40773AF405
Alexa Fluor 488 NB110-40773AF488
Alexa Fluor 532 NB110-40773AF532
Alexa Fluor 594 NB110-40773AF594
Alexa Fluor 647 NB110-40773AF647
Alexa Fluor 700 NB110-40773AF700
Alexa Fluor 750 NB110-40773AF750
Biotin NB110-40773B
DyLight 350 NB110-40773UV
DyLight 405 NB110-40773V
DyLight 488 NB110-40773G
DyLight 550 NB110-40773R
DyLight 594 NB110-40773DL594
DyLight 650 NB110-40773C
DyLight 680 NB110-40773FR
DyLight 755 NB110-40773IR
FITC NB110-40773F
HRP NB110-40773H
Janelia Fluor 549 NB110-40773JF549
Janelia Fluor 646 NB110-40773JF646

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Bioinformatics Tool for DISC1 Antibody (NB110-40773G)

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Blogs on DISC1.

Calnexin - an ER chaperone that folds the cell's glycoproteins
Calnexin is an abundant 90kDa chaperone protein that resides in the membrane of the endoplasmic reticulum. Calnexin and the related calreticulin protein function together to ensure the proper folding of glycoproteins. By binding to partially folded...  Read full blog post.

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Bioinformatics

Gene Symbol DISC1