DISC1 Products

Antibodies
Lysates
DISC1 Overexpression Lysate ( ...
DISC1 Overexpression Lysate (Native)
NBL1-09895
Species: Hu
Applications: WB
DISC1 Overexpression Lysate ( ...
DISC1 Overexpression Lysate (Native)
NBP2-08690
Species: Hu
DISC1 Overexpression Lysate ( ...
DISC1 Overexpression Lysate (Native)
NBP2-09145
Species: Hu
Proteins
DISC1 Blocking Peptide
DISC1 Blocking Peptide
NB110-40773PEP
Species: Rt
DISC1 Blocking Peptide
DISC1 Blocking Peptide
NB110-40775PEP
Species: Hu
RNAi
DISC1 RNAi
DISC1 RNAi
H00027185-R04
Species: Hu
Applications: RNAi, RNAi SP
DISC1 RNAi
DISC1 RNAi
H00027185-R03
Species: Hu
Applications: RNAi, RNAi SP
DISC1 RNAi
DISC1 RNAi
H00027185-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The Disrupted In Schizophrenia gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2 an beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Mouse
Rat
Product By Gene ID 27185
Alternate Names
  • FLJ13381
  • disrupted in schizophrenia 1 protein
  • C1orf136
  • FLJ41105
  • SCZD9
  • FLJ25311
  • KIAA0457
  • FLJ21640
  • disrupted in schizophrenia 1

Research Areas for DISC1

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Neurodegeneration
Neuroscience

Bioinformatics Tool for DISC1

Discover related pathways, diseases and genes to DISC1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related DISC1 Blog Posts

Check out the latest blog posts on DISC1.
Calnexin - an ER chaperone that folds the cell's glycoproteins
Calnexin is an abundant 90kDa chaperone protein that resides in the membrane of the endoplasmic reticulum. Calnexin and the related calreticulin protein function together to ensure the proper folding of glycoproteins. By binding to partially folded...    Read more.
Read more DISC1 related blogs.