DISC1 Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: DISC1 Antibody [NB110-40773] - DISC1 antibody was tested in PC-12 cells at 1:100 with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and ...read more
Immunohistochemistry: DISC1 Antibody [NB110-40773] - Staining of DISC1 in human brain neurons and neuropil at 2.5ug/ml. 40X.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.85 mg/ml

DISC1 Antibody Summary

Immunogen
A synthetic peptide made to an internal region (within residues 400-500) of the rat DISC1 protein. [Swiss-Prot# Q810H6]
Localization
DISC-1 localizes to the nucleus, whereas mutant DISC-1 localization occurs mainly in the cytoplasm. It co-localizes with the following organelle structure antibodies: PD1, calnexin, GIANTIN, 58K, Rab4, LAMP-1, RAP1, KDEL, and catalase.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DISC1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry 2.5-5.0 ug/ml
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 2.5-5.0 ug/ml
Application Notes
This DISC1 antibody is useful for Immunocytochemistry/Immunofluorescence and Immunohistochemistry paraffin embedded sections.Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 24560582) The theoretical molecular weight of DISC1 is ~90 kDa. Preliminary Western Blot studies have been performed with this antibody, where several non-specific bands are seen. Due to alternative splicing, DISC1 may also run at ~75 and 100 kDa. In ICC/IF, cytoplasmic staining was observed in PC12 cells.
Control Peptide
DISC1 Peptide (NB110-40773PEP)
Publications
Read Publication using
NB110-40773 in the following applications:

Reactivity Notes

Human, rat and mouse.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
Tris-Glycine and 0.15M NaCl
Preservative
0.05% Sodium Azide
Concentration
0.85 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DISC1 Antibody

  • C1orf136
  • DISC1
  • disrupted in schizophrenia 1 protein
  • disrupted in schizophrenia 1
  • FLJ13381
  • FLJ21640
  • FLJ25311
  • FLJ41105
  • KIAA0457
  • SCZD9

Background

DISC1 (Disrupted in Schizophrenia 1) is a well known risk genes for psychiatric disorders including schizophrenia, major depression, bipolar disorder, and autism. DISC1 protein localize to cytoskeleton-rich regions in cells, including the centrosome, base of primary cilia, axon and dendritic shafts and spines. For serving its multiple functions, DISC1 interacts with CCDC88A, GSK3B, PCNT, tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1, TRAF3IP1, CHCHD6 and NDEL1. DISC1 interaction with microtubules TRAF3IP1. In neurogenesis regulation, DISC1 is essential for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development as well as in adult dentate gyrus of hippocampus. DISC1 modulates GSK3Beta activity and CTNNB1 abundance for acting as positive regulator of WNT-mediated neural progenitor proliferation. DISC1 can modulate AKT-mTOR signaling for controlling the neuron positioning, dendritic development and synapse formation which ultimately regulate newborn neurons integration during adult neurogenesis and can regulate the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Moreover, DISC1 is implicated in microtubule network formation, regulation of functional biology of centrosome as well as primary cilia, neuronal migration and microtubule mediated transport.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for DISC1 Antibody (NB110-40773)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: IHC-Fr.


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IHC-Fr
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Product General Protocols

Video Protocols

ICC/IF Video Protocol

FAQs for DISC1 Antibody (NB110-40773) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB110-40773AF405
Alexa Fluor 488 Labeled NB110-40773AF488
Alexa Fluor 647 Labeled NB110-40773AF647
Alexa Fluor 700 Labeled NB110-40773AF700
Biotin Labeled NB110-40773B
DyLight 405 Labeled NB110-40773V
DyLight 488 Labeled NB110-40773G
DyLight 550 Labeled NB110-40773R
DyLight 650 Labeled NB110-40773C
FITC Labeled NB110-40773F
HRP Labeled NB110-40773H

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Blogs on DISC1.

Calnexin - an ER chaperone that folds the cell's glycoproteins
Calnexin is an abundant 90kDa chaperone protein that resides in the membrane of the endoplasmic reticulum. Calnexin and the related calreticulin protein function together to ensure the proper folding of glycoproteins. By binding to partially folded...  Read full blog post.

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Bioinformatics

Gene Symbol DISC1
Entrez