COMT Antibody

Images

 
Western Blot: COMT Antibody [NBP2-15954] - COMT antibody detects COMT protein by Western blot analysis. A. 30 ug K562 whole cell lysate/extract 12 % SDS-PAGECOMT antibody dilution: 1:1000.
Immunohistochemistry-Paraffin: COMT Antibody [NBP2-15954] - Paraffin-embedded rat brain. COMT antibody diluted at 1:500.
Immunohistochemistry-Paraffin: COMT Antibody [NBP2-15954] - Immunohistochemical analysis of paraffin-embedded DLD1 xenograft, using antibody at 1:500 dilution.
Immunohistochemistry-Paraffin: COMT Antibody [NBP2-15954] - Paraffin-embedded Rat brain. COMT antibody diluted at 1:500.

Product Details

Summary
Reactivity Hu, Rt, RMSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.52 mg/ml

Order Details

COMT Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human COMT. The exact sequence is proprietary.
Predicted Species
Rhesus Macaque (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
COMT
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
30 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Mouse (82%), Dog (81%), Pig (85%), Bovine (83%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.52 mg/ml
Purity
Immunogen affinity purified

Alternate Names for COMT Antibody

  • catechol O-methyltransferase
  • catechol-O-methyltransferase
  • COMT
  • EC 2.1.1.6

Background

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol COMT
Entrez
Uniprot