DC-SIGN/CD209 Antibody

Western Blot: DC-SIGN/CD209 Antibody [NBP2-27408] - Analysis of DC-SIGN (CD209) in human ThP-1 lysate in the A) absence and B) presence of immunizing peptide and C) mouse RAW lysate using DC-SIGN antibody at 3 ug/ml.

• Reactivity: Hu, Mu, Pm, Pm, Pm-Or, RM
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

DC-SIGN/CD209 Antibody Summary

• Description: Novus Biologicals Rabbit DC-SIGN/CD209 Antibody (NBP2-27408) is a polyclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A portion of amino acids 320-370 from human DC-SIGN (CD209) was used as the immunogen for this antibody.
• Marker: Dendritic Cell Marker
• Predicted Species: Orangutan (100%), Baboon (94%), Rhesus Macaque (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CD209
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 2-4ug/ml

Reactivity Notes

Based upon immunogen sequence similarity, this antibody is predicted to react with: Chimpanzee (100%), Black crested gibbon (98%), Lar gibbon (98%), southern pig-tailed macaque (98%), African green monkey (94%), siamang (92%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein A purified

Alternate Names for DC-SIGN/CD209 Antibody

• CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin
• CD209 molecule
• CD209
• CDSIGNHIV gpl20-binding protein
• CLEC4L
• CLEC4LC-type lectin domain family 4 member L
• DCSIGN
• DC-SIGN
• DC-SIGN1
• DC-SIGN1C-type lectin domain family 4, member L
• DC-SIGNMGC129965
• Dendritic cell-specific ICAM-3-grabbing non-integrin 1

Background

DC-SIGN, also called CD209, is a C type lectin receptor and an acronym for Dendritic Cell-Specific intracellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin protein. DC-SIGN (CD209) is a 45kDa receptor which binds mannans and glycans on bacteria, viruses and fungi (1). Expressed on Dendritic Cells (DCs) and DC-like macrophages, DC-SIGN is an important cell interaction molecule mediating DC-T cell or DC-Neutrophil responses. DC-SIGN is especially important in DC Th1 interaction, regulating Th1 activity through it's role as a pathogen receptor (2-4). Interaction between DC-SIGN and TLR4 has been demonstrated for induction of inflammatory responses (5). As a CLR and innate immune receptor, DC-SIGN detection and quantitation with antibody probes are used as both a phenotype and indicator of a functional role in anti-microbial responses of DC's.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CD209