DC-SIGN/CD209 Products

Description

DC-SIGN encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Bioinformatics

Entrez	30835 Human
Uniprot	NM_021155 Human NP_066978 Human NP_066978.1 Human Q9NNX6 Human
Product By Gene ID	30835
Alternate Names	CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin CD209 molecule CDSIGNHIV gpl20-binding protein CLEC4LC-type lectin domain family 4 member L DC-SIGN1C-type lectin domain family 4, member L DC-SIGNMGC129965 Dendritic cell-specific ICAM-3-grabbing non-integrin 1

Research Areas for DC-SIGN/CD209

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Virology, Bacteria and Parasites