DC-SIGN/CD209 Products

Antibodies
Antibody Pairs
DC-SIGN/CD209 Antibody Pair
DC-SIGN/CD209 Antibody Pair
H00030835-PW1
Species: Hu
Applications: WB, IP
DC-SIGN/CD209 Antibody Pair
DC-SIGN/CD209 Antibody Pair
H00030835-AP11
Species: Hu
Applications: S-ELISA
DC-SIGN/CD209 Antibody Pair
DC-SIGN/CD209 Antibody Pair
H00030835-PW2
Species: Hu
Applications: WB, IP
Lysates
DC-SIGN/CD209 Overexpression ...
DC-SIGN/CD209 Overexpression Lysat...
NBL1-08921
Applications: WB
DC-SIGN/CD209 Overexpression ...
DC-SIGN/CD209 Overexpression Lysat...
H00030835-T01
Applications: WB
Proteins
DC-SIGN/CD209 Partial Recombi ...
DC-SIGN/CD209 Partial Recombinant ...
H00030835-Q01
Species: Hu
Applications: WB, ELISA, PA
DC-SIGN/CD209 Recombinant Pro ...
DC-SIGN/CD209 Recombinant Protein
H00030835-P01
Species: Hu
Applications: WB, ELISA, PA
DC-SIGN/CD209 Peptide
DC-SIGN/CD209 Peptide
NBP1-76787PEP
Species: Hu
Applications: AC
RNAi
DC-SIGN/CD209 RNAi
DC-SIGN/CD209 RNAi
H00030835-R01
Species: Hu

Description

DC-SIGN encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 30835
Alternate Names
  • CDSIGNHIV gpl20-binding protein
  • CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin
  • DC-SIGN1C-type lectin domain family 4, member L
  • DC-SIGNMGC129965
  • CLEC4LC-type lectin domain family 4 member L
  • Dendritic cell-specific ICAM-3-grabbing non-integrin 1
  • CD209 molecule

Research Areas for DC-SIGN/CD209

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Virology, Bacteria and Parasites

PTMs for DC-SIGN/CD209

Learn more about PTMs related to DC-SIGN/CD209.

Phosphorylation
Glycosylation
Methylation
Deglycosylation
Demethylation
Cleavage
Citrullination
Acetylation

Bioinformatics Tool for DC-SIGN/CD209

Discover related pathways, diseases and genes to DC-SIGN/CD209. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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