DC-SIGN/CD209 Antibody

Images

 
Western Blot: DC-SIGN/CD209 Antibody [NBP1-77284] - Detection of DC-SIGN in human small intestine at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: DC-SIGN/CD209 Antibody [NBP1-77284] - Immunohistochemical analysis of DC-SIGN in human lymph node tissue with DC-SIGN antibody at 10 ug/ml.
Immunofluorescence: DC-SIGN/CD209 Antibody [NBP1-77284] - Immunofluorescence of DC-SIGN in Human Lymph Node tissue with DC-SIGN antibody at 20 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

DC-SIGN/CD209 Antibody Summary

Immunogen
Antibody was raised against a synthetic peptide corresponding to 21 amino acids near the center of human DC-DIGN. The immunogen is located within the last 50 amino acids of DC-SIGN.
Marker
Dendritic Cell Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CD209
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunofluorescence 20 ug/ml
Application Notes
DC-SIGN antibody can be used for detection of DC-SIGN by Western blot at 1 to 2 mg/ml. A band at approximately 44 kDa can be detected.
Theoretical MW
47 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
DC-SIGN/CD209 Peptide (NBP1-77284PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DC-SIGN/CD209 Antibody

  • CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin
  • CD209 molecule
  • CD209
  • CDSIGNHIV gpl20-binding protein
  • CLEC4L
  • CLEC4LC-type lectin domain family 4 member L
  • DCSIGN
  • DC-SIGN
  • DC-SIGN1
  • DC-SIGN1C-type lectin domain family 4, member L
  • DC-SIGNMGC129965
  • Dendritic cell-specific ICAM-3-grabbing non-integrin 1

Background

Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CD209
Entrez
Uniprot