D4-GDI/RhoGDI2 Antibody (10D774) [Biotin]

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Product Details

Summary
Reactivity Hu, Bv, Ca, Ch, EqSpecies Glossary
Applications ELISA
Clone
10D774
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

D4-GDI/RhoGDI2 Antibody (10D774) [Biotin] Summary

Immunogen
A synthetic peptide corresponding to human D4-GDI/RhoGDI2 was used as the immunogen.
Specificity
A 28 kDa band is observed.
Predicted Species
Bovine (100%), Canine (100%), Chicken (100%), Equine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
ARHGDIB
Purity
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1-2 ug/ml
Readout System
Positive Control
D4-GDI/RhoGDI2 Lysate (NBL1-07674)
Publications
Read Publication using NB100-55788.

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for D4-GDI/RhoGDI2 Antibody (10D774) [Biotin]

  • ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
  • D4
  • GDIA2
  • GDID4
  • LYGDI
  • Ly-GDI
  • RAP1GN1
  • RhoGDI2

Background

D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for D4-GDI/RhoGDI2 Antibody (NB100-55788)(1)


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FAQs for D4-GDI/RhoGDI2 Antibody (NB100-55788) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-56556APC
DyLight 350 Labeled NB100-56556UV
DyLight 405 Labeled NB100-56556V
DyLight 488 Labeled NB100-56556G
DyLight 550 Labeled NB100-56556R
DyLight 650 Labeled NB100-56556C
DyLight 680 Labeled NB100-56556FR
DyLight 755 Labeled NB100-56556IR
HRP Labeled NB100-56556H
PE Labeled NB100-56556PE
PerCP Labeled NB100-56556PCP

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Blogs on D4-GDI/RhoGDI2.

D4-GDI (GDP dissociation inhibitor, RhoGD12)
The D4-GDI protein is a negative regulator of the Ras-related Rho family of small molecule "molecular switch" GTPases. The Rho GTPases modify cell structure and architecture via rapid changes to the actin cytoskeleton and cell membrane. M...  Read full blog post.

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Bioinformatics

Gene Symbol ARHGDIB

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