The epitope recognized by this antibody is sensitive to bromelain and other proteolytic enzymes. It is detectable in routine formalin-fixed, paraffin-embedded tissue. The antibody is also reactive with bone marrow nucleated cells, medullary thymocytes, liver Kupffer cells, fibroblasts, corneal cells, epidermal keratinocytes, synovial cells, a subset of pancreatic acinar cells and brain cells.
Read Publication using NB600-1457 in the following applications:
Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.
10mM PBS (pH 7.4) and 1.0% BSA
15mM Sodium Azide
Protein A or G purified
Alternate Names for CD44 Antibody (A3D8)
CD44 molecule (Indian blood group)
cell surface glycoprotein CD44
chondroitin sulfate proteoglycan 8
Extracellular matrix receptor III
GP90 lymphocyte homing/adhesion receptor
hematopoietic cell E- and L-selectin ligand
Heparan sulfate proteoglycan
homing function and Indian blood group system
MDU2CD44 antigen (homing function and Indian blood group system)
Phagocytic glycoprotein 1
Phagocytic glycoprotein I
CD44 is a type 1 transmembrane glycoprotein also known as Phagocytic Glycoprotein 1 (pgp 1) and HCAM. CD44 is the receptor for hyaluronate and exists as a large number of different isoforms due to alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells, and erythrocytes is a glycosylated type 1 transmembrane protein. Other isoforms contain glycosaminoglycans and are expressed on hematopoietic and non hematopoietic cells. CD44 is involved in adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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