CCR6 Antibody (DMC477) - Chimeric

• Reactivity: Hu
• Applications: Flow
• Clone: DMC477
• Clonality: Monoclonal
• Host: Human
• Conjugate: Unconjugated
• Concentration: LYOPH

CCR6 Antibody (DMC477) - Chimeric Summary

• Description: This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: CCR6 recombinant protein expressed in mammalian cells (Accession# P51684). The exact amino acid sequence is proprietary.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Gene: CCR6
• Purity: Antigen Affinity-purified from cell culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:100

Packaging, Storage & Formulations

• Storage: Store at -20C in powder form. Store at -80C once reconstituted.
• Buffer: PBS, pH 7.4, 5-8% Trehalose
• Preservative: Trehalose
• Concentration: LYOPH
• Purity: Antigen Affinity-purified from cell culture supernatant
• Reconstitution Instructions: Dissolve the lyophilized antibody in sterile and low endotoxin water. The recommend volume of water is lot specific. Please refer to the instructions printed on the product vial or contact technical support.

Alternate Names for CCR6 Antibody (DMC477) - Chimeric

• BN-1
• CC-CKR-6
• CCR6
• CCR-6
• CD196 antigen
• CD196
• chemokine (C-C motif) receptor 6
• CKRL3
• CKR-L3
• CKR-L3G-protein coupled receptor 29
• CKRL3LARC receptor
• CMKBR6
• CMKBR6STRL22
• DRY6
• GPR29
• GPR29C-C CKR-6
• GPRCY4
• GPR-CY4
• GPRCY4DRY-6
• lymphocyte, 22
• STRL22

Background

CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. It is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP 3 alpha). This receptor has been shown to be important for B lineage maturation and antigen driven B cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CCR6