CCR6 Antibody (53103)

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CCR6 was detected in immersion fixed paraffin-embedded sections of human spleen using 25 µg/mL Human CCR6 Monoclonal Antibody (Catalog # MAB195) overnight at 4 °C. Before incubation with the primary ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, CyTOF-ready
Clone
53103
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

CCR6 Antibody (53103) Summary

Additional Information
Clone 53103 was used by HLDA to establish CD designation
Immunogen
NS0 mouse myeloma cell line transfected with human CCR6
Met1-Met374
Accession # P51684
Specificity
Detects human CCR6. Stains human CCR6 transfectants but not the parental cell line in flow cytometry. Does not cross-react with transfectants expressing human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4, or STRL33.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CCR6
Purity
Protein A or G purified from ascites
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 2.5 ug/10^6 cells
  • Immunohistochemistry 8-25 ug/mL
  • CyTOF-ready
Publications
Read Publications using
MAB195 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from ascites
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CCR6 Antibody (53103)

  • BN-1
  • CC-CKR-6
  • CCR6
  • CCR-6
  • CD196 antigen
  • CD196
  • chemokine (C-C motif) receptor 6
  • CKR-L3G-protein coupled receptor 29
  • CKRL3LARC receptor
  • CMKBR6STRL22
  • DRY6
  • GPR29
  • GPR29C-C CKR-6
  • GPR-CY4
  • GPRCY4DRY-6
  • lymphocyte, 22
  • STRL22

Background

CCR6 is a seven transmembrane-spanning G protein-coupled receptor that binds the chemokine MIP-3 alpha and mediates the chemoattraction of B and T lymphocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CCR6 Antibody (MAB195)(29)

We have publications tested in 4 confirmed species: Human, Mouse, Primate, Rhesus Macaque.

We have publications tested in 7 applications: Flow, ICC, IHC, IHC Frozen, IHC Paraffin-embedded, IHC-P, WB.


Filter By Application
Flow
(10)
ICC
(4)
IHC
(2)
IHC Frozen
(1)
IHC Paraffin-embedded
(6)
IHC-P
(4)
WB
(2)
All Applications
Filter By Species
Human
(25)
Mouse
(2)
Primate
(1)
Rhesus Macaque
(1)
All Species
Showing Publications 1 - 10 of 29. Show All 29 Publications.
Publications using MAB195 Applications Species
T Balzano, J Forteza, P Molina, J Giner, A Monzó, J Sancho-Jim, A Urios, C Montoliu, V Felipo The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons Sci Rep, 2018;8(1):3004. 2018 [PMID: 29445232] (IHC-P,, Human) IHC-P Human
XP Zhang, ZJ Hu, AH Meng, GC Duan, QT Zhao, J Yang Role of CCL20/CCR6 and the ERK signaling pathway in lung adenocarcinoma Oncol Lett, 2017;14(6):8183-8189. 2017 [PMID: 29250193] (IHC-P,, Human) IHC-P Human
B Soto, T Gallastegi, C Rodríguez, J Martínez-G, JR Escudero, L Vila, M Camacho Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm Sci Rep, 2017;7(1):17331. 2017 [PMID: 29229985] (IHC-P,, Human) IHC-P Human
R Diao, T Wang, KL Fok, X Li, Y Ruan, MK Yu, Y Cheng, Y Chen, H Chen, L Mou, X Cai, Y Wang, Z Cai, X Zeng, HC Chan CCR6 is required for ligand-induced CatSper activation in human sperm Oncotarget, 2017;8(53):91445-91458. 2017 [PMID: 29207656] (ICC,, Human) ICC Human
J Dunham, N van Driel, BJ Eggen, C Paul, BA 't Hart, JD Laman, YS Kap Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset Clin Transl Immunology, 2017;6(2):e127. 2017 [PMID: 28243437] (Flow,, Primate) Flow Primate
W Szczeklik, B Jakie?a, K Wawrzycka-, M Sanak, M Hubalewska, A Padjas, M Surmiak, K Szczeklik, J Sznajd, J Musia? Skewing towards Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis Eur. J. Immunol, 2017;0(0):. 2017 [PMID: 28155222] (Flow,, Human) Flow Human
Valentina Cecchinato Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization J. Immunol, 2016;0(0):. 2016 [PMID: 27895171] (IHC-P,, Rhesus Macaque) IHC-P Rhesus Macaque
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition Br J Cancer, 2016;0(0):. 2016 [PMID: 27149649] (Flow,, Human) Flow Human
Schanz A, Red-Horse K, Hess A, Baston-Bust D, Heiss C, Krussel J Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression. Placenta, 2014;35(12):1089-94. 2014 [PMID: 25293376] (WB,, Human) WB Human
Liu, Jinlin, Ke, Fang, Xu, Zhenyao, Liu, Zhaoyuan, Zhang, Lingyun, Yan, Sha, Wang, Zhe, Wang, Hong, Wang, Honglin CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. PLoS ONE, 2014;9(6):e101137. 2014 [PMID: 24979261] (IHC,, Mouse) IHC Mouse
Show All 29 Publications.

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Bioinformatics

Gene Symbol CCR6
Entrez
Uniprot