CCR6 Antibody (18B9E6)


Western Blot: CCR6 Antibody (18B9E6) [NBP2-25220] - analysis of A) mouse EL4, B) conA treated EL4 lysate and C) partial recombinant protein using CD196 (CCR6) antibody at 2 ug/ml.
Immunohistochemistry-Paraffin: CCR6 Antibody (18B9E6) [NBP2-25220] - Formalin-fixed, paraffin-embedded normal mouse testis tissue stained with CD196 (CCR6) antibody (5 ug/ml), peroxidase-conjugate and DAB chromogen. more

Product Details

Reactivity MuSpecies Glossary
Applications WB, IHC, IHC-P
0.5 mg/ml

CCR6 Antibody (18B9E6) Summary

A recombinant protein consisting of the external domains of mouse CD196 (CCR6) was used as the immunogen for the antibody.
IgG2a Kappa
Protein G purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
CD196 (CCR6) antibody at 0.5 mg/ml in PBS, 0.05% BSA
0.05% Sodium Azide
0.5 mg/ml
Protein G purified


  • Western Blot 2-5 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml
Application Notes
Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.

Alternate Names for CCR6 Antibody (18B9E6)

  • BN-1
  • CC-CKR-6
  • CCR6
  • CCR-6
  • CD196 antigen
  • CD196
  • chemokine (C-C motif) receptor 6
  • CKR-L3G-protein coupled receptor 29
  • CKRL3LARC receptor
  • DRY6
  • GPR29
  • GPR29C-C CKR-6
  • GPR-CY4
  • lymphocyte, 22
  • STRL22


CD196 (CCR6) is a chemokine receptor expressed on Th17 cells and regulatory Tcells that is induced by T-cell priming with certain cytokines. This protein plays a pivotal role in directing inflammatory and regulatory cells to inflamed tissues or the gut, where the ligand of CD196, CCL20 is expressed. Although most chemokine-chemokine receptor interactions are characterized by a high promiscuity, CD196 binds only CCL20 and -defensins. This chemokine receptor is widely expressed on human blood and tissue leukocytes, including subsets of dendritic cells, CD45RO+ effector/memory Tcells, CD25 high regulatory Tcells (Tregs), naive and memory B cells, NKT cells, and NK cells. On memory Tcells, CD196 is expressed on a population of autoreactive interleukin-10 (IL-10)-producing cells and subsets of skin- and mucosa-homing cells. More recently, CD196 was identified as a new risk factor for rheumatoid arthritis; moreover, a nucleotide polymorphism within the Cd196locus was shown to be associated with susceptibility to rheumatoid arthritis, Graves disease, and Crohn disease (Steinfelder S et al,.2011).This protein also acts as a marker for Th17 lineage polarization and HIV permissiveness in memory CD4+ Tcells. CD196+ Tcells have the potential to migrate into the GALT via the gut-homing integrin 47, a newly identified HIV-gp120 binding receptor. Nevertheless, given the ability of integrin 7 to regulate cell migration into the GALT and bind HIV-gp120, CD196+ Tcells coexpressing integrin 7 and CCR5 might have an extraordinary ability to disseminate HIV from the portal sites of entry (Monteiro P et al. 2011). Anti-CD196 antibody could almost completely suppress the cell migration induced by hBD-2 (Human beta-defensin-2), suggesting that hBD-2 mainly utilizes CD196 (CCR6) as a functional receptor (Niyonsaba F et al,.2004).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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WB Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Allophycocyanin Labeled NBP2-25224APC
Biotin Labeled NBP2-25224B
DyLight 350 Labeled NBP2-25224UV
DyLight 405 Labeled NBP2-25224V
DyLight 405LS Labeled NBP2-25224V3
DyLight 488 Labeled NBP2-25224G
DyLight 550 Labeled NBP2-25224R
DyLight 650 Labeled NBP2-25224C
DyLight 680 Labeled NBP2-25224FR
DyLight 755 Labeled NBP2-25224IR
HRP Labeled NBP2-25224H
PE Labeled NBP2-25224PE
PerCP Labeled NBP2-25224PCP

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Gene Symbol CCR6

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