Western Blot: CCR2 Antibody [NBP1-48337] - WB analysis of CCR2 in rat lysate. Image courtesy of product review submitted by Rasha Elbaz.
Immunocytochemistry/ Immunofluorescence: CCR2 Antibody [NBP1-48337] - Analysis of CCR2 in HeLa cells
Immunohistochemistry-Paraffin: CCR2 Antibody [NBP1-48337] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human normal breast using 5 ug/ml concentration of CCR2 antibody. The breast ductal/acinar ...read more
Immunohistochemistry-Paraffin: CCR2 Antibody [NBP1-48337] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human liver cancer using 5 ug/ml concentration of CCR2 antibody. Intense ...read more
Immunohistochemistry-Paraffin: CCR2 Antibody [NBP1-48337] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human rectal adenocarcinoma using 5 ug/ml concentration of CCR2 antibody. The cancerous ...read more
Immunohistochemistry-Paraffin: CCR2 Antibody [NBP1-48337] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human esophageal squamous cell carcinoma (SCC) using 5 ug/ml concentration of CCR2 antibody. ...read more
Immunohistochemistry-Paraffin: CCR2 Antibody [NBP1-48337] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human normal kidney using 5 ug/ml concentration of CCR2 antibody. Strong cytoplasmic ...read more
This CCR2 antibody is useful for Flow Cytometry, Immunohistochemistry-Paraffin and Immunocytochemistry/Immunofluorescence applications. Some customers have also reported success using this antibody for WB on rat and human lysates.
Human. Reactivity with Rat reported by varified customer. The immunogen sequence similarity with other species: Rhesus monkey and several other primate species (100%), Mouse (69%).
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
PBS and 30% Glycerol
0.1% Sodium Azide
Immunogen affinity purified
Alternate Names for CCR2 Antibody
C-C chemokine receptor type 2
chemokine (C-C motif) receptor 2
Monocyte chemoattractant protein 1 receptor
monocyte chemotactic protein 1 receptor
CCR2 is a major chemokine receptor expressed on monocytes and its activation through its ligands MCP1, MCP2, MCP3 and MCP4 (systematic names CCL2, CCL8, CCL7 and CCL13, respectively) stimulates the migration of monocytes across the vascular wall into tissues wherein they facilitate chronic inflammation. CCR2 is a member of GPCR1 family and is up-regulated by CREB3. It is a multi-pass membrane protein found in cell membrane, and besides monocytes, it is also found on other cell types like NK cells, macrophages, immature dendritic cells, gamma delta T cells, and activated T cells (including Th17 cells). There are two alternatively spliced forms of CCR2: CCR2A - the major isoform expressed by mononuclear cells and vascular smooth muscle cells; and CCR2B - expressed predominantly by monocytes and activated NK cells. CCR2 has both pro-inflammatory (mediated by APC and T cells) and anti-inflammatory (mediated by regulatory T cells) activities. Besides inflammation, it has been implicated several pathologies including HIV-1/AIDS, autoimmune disorders (psoriasis, rheumatoid arthritis, and multiple sclerosis), pulmonary diseases (asthma, COPD), vascular disease and cancer (prostate cancer).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for CCR2 Antibody (NBP1-48337). (Showing 1 - 1 of 1 FAQ).
Can you tell if NBP1-48337 could work on mouse tissue? Based on the comparison of the UniProt sequences it is difficult to tell for the 20-100 AA sequence. Could you do a homology check with the real used immunogen and let us know if it would be worth while testing on mouse?
The immunogen for this antibody shares 69% similarity with mouse, so it is not predicted to cross-react. However, the immunogen also shares 69% similarity with rat and it has been shown to cross-react with rat by customers, so it may certainly work in mouse as well although it is not predicted. If you would be interested in testing this novel species, please take a look at our Innovator's Reward program.
CCR2 or CD192 CCR2 is a receptor for several monocyte chemoattractant proteins (MCP1, MCP3, MCP4) that specifically govern monocyte chemotaxis. CCR2 transduces its downstream signals through increasing intracellular calcium ion levels. For example, MCP1 regulate... Read full blog post.
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