BDNF Antibody (EPR1292)

Product Discontinued

BDNF Antibody (EPR1292) Summary

• Immunogen: A synthetic peptide corresponding to residues in human BDNF was used as an immunogen.
• Clonality: Monoclonal
• Host: Rabbit
• Gene: BDNF
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100 - 250
  • Western Blot 1:1000 - 10000

Reactivity Notes

Reacts with: Mouse, Rat, Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 49% PBS, 0.05% BSA and 50% Glycerol
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for BDNF Antibody (EPR1292)

• Abrineurin
• ANON2
• BDNF
• brain-derived neurotrophic factor
• BULN2
• MGC34632
• Neurotrophin

Background

Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a polypeptide factor initially regarded to be responsible for neuron proliferation, differentiation and survival through its uptake at nerve terminals and retrograde transport to the cell body (1). BDNF has been linked to a variety of neurological and psychological conditions such as Huntington's disease, Alzheimer's disease, depression and anxiety. Studies show that transgenic overexpression of the neurotrophin BDNF has an unexpected facilitatory effect on anxiety-like behavior, concomitant with increased spinogenesis in the basolateral amygdala (2). In addition, BDNF enhances the neurite outgrowth on immature astrocytes. A multifactorial strategy based on transplantation of neonatal astrocytes in the presence of additional BDNF may stimulate axon regrowth after experimental injury to the central nervous system (3). The precursor pro-BDNF is 27-34 kDa before proteolytic cleavage, whereas the mature form of BDNF is 14 kDa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BDNF
• Uniprot:
  • P23560()