Angiopoietin-2 Antibody (748246) [HRP]

• Reactivity: Mu
• Applications: WB
• Clone: 748246
• Clonality: Monoclonal
• Host: Rat
• Conjugate: HRP

Angiopoietin-2 Antibody (748246) [HRP] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant mouse Angiopoietin-2
  Asp68-Phe496
  Accession # O35608
• Specificity: Detects mouse Angiopoietin-2 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant mouse (rm) Angiopoietin‑1, rmAngiopoietin-3, recombinant human (rh) Angiopoietin‑2, and rhAngiopoietin-4 is observed. In Western blots, 100% cross‑reactivity with rmAngiopoietin-1 is observed and less than 10% cross‑reactivity with rhAngiopoietin-2, rhAngiopoietin-4, and rmAngiopoietin-3 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: ANGPT2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for Angiopoietin-2 Antibody (748246) [HRP]

• AGPT2
• ANG2
• ANG-2
• angiopoietin 2
• Angiopoietin-2
• angiopoietin-2a
• angiopoietin-2B
• angiopoitin 2
• ANGPT2
• Tie2-ligand

Background

Angiopoietin 1 and Angiopoietin 2 are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie 2/Tek. Angiopoietin 2 is only 60% homologous with Angiopoietin 1. Angiopoietin 1 binding to Tie 2/Tek causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodeling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ANGPT2