ABCA1 Antibody [FITC]


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Product Details

Reactivity Hu, Mu, Rt, Po, Ca, Ch, Ha, MdSpecies Glossary
Applications ELISA, Flow

ABCA1 Antibody [FITC] Summary

Partial peptide sequence (within residues 1100-1300) of human ABCA1 [UniProt# O95477]. Actual immunogen sequence is proprietary information.
Astrocyte Marker
Immunogen affinity purified
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  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This ABCA1 antibody is useful for Flow Cytometry, Immunocytochemistry/Immunofluorescence (PMID: 21501868), Western blot and Immunohistochemistry on frozen and paraffin embedded sections. In Western blot a band representing ABCA1 is observed at ~220 kDa. Additional non-specific bands are seen at lower molecular weights, but do not interfere with the ABCA1 signal. ELISA has been reported in scientific literature.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
220 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reviewed Applications
Read 1 Review rated 5
NB400-105F in the following applications:

Reactivity Notes

Canine reactivity reported in scientific literature (PMID: 24612239)

Packaging, Storage & Formulations

Store at 4C in the dark.
0.05% Sodium Azide
Immunogen affinity purified


This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for ABCA1 Antibody [FITC]

  • ABC1
  • ABC-1
  • ABC1ATP-binding cassette transporter A1
  • ABCA1
  • ATP-binding cassette 1
  • ATP-binding cassette transporter 1
  • ATP-binding cassette, sub-family A (ABC1), member 1
  • CERP
  • Cholesterol efflux regulatory protein
  • EC
  • EC
  • EC 3.6.3
  • EC
  • FLJ14958
  • HDLDT1
  • membrane-bound
  • MGC164864
  • MGC165011
  • TGD
  • TGDATP-binding cassette sub-family A member 1


ABCA1 (ATP-binding cassette transporter A1), ATP-binding cassette transporter family member, is a cAMP-dependent and sulfonylurea-sensitive anion transporter which is involved in the regulation of apolipoprotein AI (apoAI)-mediated cholesterol efflux from macrophages and act as a key gatekeeper influencing intracellular cholesterol transport. ABCA1 is widely expressed with highest expression levels found in macrophages and is induced by bacterial LPS which regulates its expression through LXR (liver X receptor) -independent mechanism. ABCA1 interacts with MEGF10 and its expression is repressed by ZNF202. ABCA1 phosphorylation at Ser-2054 site regulates the phospholipid efflux and DHHC8 mediated palmitoylation of ABCA1 is essential for its membrane localization. ABCA1 expressed in brain neurons/glia mediates cholesterol transport to apoE which is the major CNS apolipoprotein, and it influences the motor function and synaptic morphology also. Defects in ABCA1 have been linked to HDLD1 (high density lipoprotein deficiency type 1; also known as analphalipoproteinemia, Tangier disease or TGD) and HDLD2 (high density lipoprotein deficiency type 2; also known as familial hypoalphalipoproteinemia or FHA).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Review for ABCA1 Antibody (NB400-105F) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using NB400-105F:
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Images Ratings Applications Species Date Details
Flow Cytometry ABCA1 NB400-105F
reviewed by:
Shawn Rose
Flow Human 04/28/2014


ApplicationFlow Cytometry
Sample Testedhuman adipose tissue macrophages


Blocking Details10% bovine serum in PBS

Primary Anitbody

Dilution RatioABCA-1


Detection NotesLSRII flow cytometer
Fixation Detailsfreshly isolated cells by collagenase digestion
Permeabilization Detailsnot applicable
Wash Descriptionsame as above

Product General Protocols

Video Protocols

ICC/IF Video Protocol

FAQs for ABCA1 Antibody (NB400-105F). (Showing 1 - of FAQ).

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    ABCA1 - The Caretaker for Cholesterol Transportation
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    SREBP: Gatekeeper of Cholesterol Homeostasis
    SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g....  Read full blog post.

    SREBP2: From Cholesterol Homeostasis to Cancer Invasion
    Sterol-regulatory-element-binding protein 2 (SREBP2) is a transcription factor that regulates cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. HMG-CoA. Along with another transcription factor LXR, SREBP...  Read full blog post.

    LXR Alpha, ABCA1 and Cholesterol Homeostasis
    LXR Alpha, also known as Liver X receptor Alpha is a 50KDa protein that belongs to the nuclear hormone receptor family located in the nucleus. It is specifically expressed in the liver, kidney and intestine; however it has also been found in the splee...  Read full blog post.

    The ABCA1 Antibody and ABC Transporter Research
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    Recent Reviews


    Shawn Rose
    Application: Flow
    Species: Human


    Gene Symbol ABCA1