ABCA1

Niemann Pick-C1 and cholesterol dynamics

Niemann-Pick type C1 (NPC1) mediates low-density cholesterol transport from late endosomes and lysosomes to other areas of the cell via receptor mediation endocytosis.  Although cholesterol moves freely inside the cell, it cannot independently export out of the lysosome, which is where NPC1 steps in.

ABCA1 (ATP-binding cassette transporter A1)

The ABCA1 molecule is a primary gatekeeper for regulating the intracellular transport of cholesterol. It belongs to a larger related multifamily of cAMP-dependent anion transporter cell membrane molecules. These key proteins are responsible for trafficking the reverse efflux of cholesterol from cells into peripheral tissues using the apolipoprotein A-1 (apo) carrier. In particular, the ABCA1 molecule exhibits a diverse expression profile and is found most highly expressed in macrophages.

ABCA1 - The Caretaker for Cholesterol Transportation

The ATP-binding cassette transporter A1 (ABCA1) protein is a key gatekeeper for regulating intracellular cholesterol transport. It is one member of a large family of genes comprised of cAMP-dependent anion transporter cell membrane proteins. These important proteins regulate reverse cholesterol efflux from cells into the peripheral tissues via apolipoprotein A-1 (apo). ABCA1 in particular has a diverse expression profile and is most highly expressed in macrophages.

ABCG8: Cholesterol's Fate

The ATP-binding cassette (ABC) transporter genes are key gatekeeper molecules that regulate the amount of dietary cholesterol retained by the body. They are a multifamily comprised of cAMP-dependent anion transporter cell membrane proteins that monitor reverse cholesterol efflux from cells into the peripheral tissues via apolipoprotein A-I (Apo). ABCG8 is expressed at high levels in the liver and intestine.

ABCA1

ABCA1 is a key gatekeeper influencing intracellular cholesterol transport, and is an important member of a multifamily of cAMP-dependent anion transporter cell membrane proteins that regulate reverse cholesterol efflux from cells in peripheral tissues to apolipoprotein A1. ABCA1 has a wide expression profile with highest expression levels found in macrophages.

SREBP: Gatekeeper of Cholesterol Homeostasis

SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. HMG-CoA. The SREBP1 antibody was used in fundamental studies to dissect SREBP1 domains and downstream signaling (1).

SREBP2: From Cholesterol Homeostasis to Cancer Invasion

LXR Alpha, ABCA1 and Cholesterol Homeostasis

LXR Alpha, also known as Liver X receptor Alpha is a 50KDa protein that belongs to the nuclear hormone receptor family located in the nucleus. It is specifically expressed in the liver, kidney and intestine; however it has also been found in the spleen, macrophages and the adrenals. All of these tissues play an important role in lipid metabolism. The primary role of LXR Alpha is to maintain cholesterol homeostasis in macrophages by regulating the genes involved in this.

The ABCA1 Antibody and ABC Transporter Research

The ABC (ATP-binding cassette) transporters are a superfamily of transmembrane proteins which play an essential role in membrane transport in both prokaryotes and eukaryotes. In humans, ABC transporters have been implicated in many conditions. For example, ABCA1 antibody research has shown mutations in the ABCA1 gene can cause Tangier disease, while the ABCB family causes multiple drug resistance.

Exploring how ABCG8 Affects Heart Disease

The high prevalence of atherosclerosis in developed nations is not breaking news; it has been well established that heart disease is the leading cause of death in the United States, and it presents a major socioeconomic burden.

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