ABCA4 Antibody (3F4)

Images

 
Immunohistochemistry: ABCA4 Antibody (3F4) [NBP1-30032] - staining of adult mouse retina showing specific immunolabeling of the ABCA4 protein. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.

Product Details

Summary
Reactivity Hu, Mu, Bv, XpSpecies Glossary
Applications WB, IHC, IHC-Fr
Clone
3F4
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

ABCA4 Antibody (3F4) Summary

Immunogen
Partially purified bovine 220 kDa disc rim protein
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ABCA4
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
Although not confirmed, this product may be useful in Paraffin. Immunohistochemistry-Frozen was reported in scientific literature.
Theoretical MW
220 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NBP1-30032 in the following applications:

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Protein G purified

Alternate Names for ABCA4 Antibody (3F4)

  • ABC10
  • ABCRRMP
  • ARMD2DKFZp781N1972
  • ATP binding cassette transporter
  • ATP-binding cassette sub-family A member 4
  • ATP-binding cassette transporter, retinal-specific
  • ATP-binding cassette, sub-family A (ABC1), member 4
  • ATP-binding transporter, retina-specific
  • CORD3
  • EC 3.6.3
  • FFMFLJ17534
  • photoreceptor rim protein
  • retinal-specific ATP-binding cassette transporter
  • retina-specific ABC transporter
  • RIM ABC transporter
  • RIM protein
  • RmP
  • RP19
  • Stargardt disease protein
  • STGD
  • STGD1

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for ABCA4 Antibody (NBP1-30032)(2)

We have publications tested in 2 confirmed species: Bovine, Xenopus.

We have publications tested in 1 application: IHC-Fr.


Filter By Application
IHC-Fr
(2)
All Applications
Filter By Species
Bovine
(1)
Xenopus
(1)
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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ABCA4
Entrez