ABCA1 Mutations: A Risk Factor in Atherosclerosis Related Strokes

Mon, 02/21/2011 - 08:03

The ATP Binding Cassette Transporter (ABCA1) gene encodes the cholesterol regulatory efflux protein, which plays a key role in lipid metabolism. ABCA1 antibody products are an important part of any antibody catalog covering atherosclerosis disease research.

Atherosclerosis (narrowing of the arteries) is characterized by a build-up of fatty plaques, containing cholesterol, causing arteries to narrow. These plaques can then become ulcerated, causing blood clots to form. If this occurs in the carotid arteries the clots can travel to the brain, causing a stroke. In the general population, low plasma HDLC levels are well documented to increase the risk of coronary heart disease.

ABCA1 antibody studies in animal models have shown ABCA1 gene mutations increase the risk of atherosclerosis. Researchers also discovered that oxidation of LDL in the cells of the arterial wall is modulated by ABCA1. In atherosclerotic plaques, ABCA1 upregulation occurred, suggesting a link between ABCA1 expression and the formation of plaques. Results also suggested ABCA1 polymorphisms can affect lipid profiles, and that ABCA1 may play an essential role in regulating ApoA-I and ApoE levels in the brain.

Western Blot: ABCA1 Antibody

In humans, a 2005 Hungarian study of stroke patients suggested two ABCA1 polymorphisms which may offer protection from strokes. However, a similar study by Pasdar, et al. in 2007 showed no significant effect – positive or negative - in four ABCA1 polymorphisms, although they reported a change in serum lipid levels.

In 2009, P. Isoviita, et al. conducted CD36 and ABCA1 antibody assay studies on carotid plaques (CPs). The results suggested that an imbalance between lipid efflux and influx, represented by CD36 and ABCA1 levels, could lead to carotid plaque build-up, intraplaque hemorrhages and increased stroke risk. Novus Biologicals offers an extensive ABCA1 antibody catalog covering heart disease and lipid/cholesterol metabolism antibody research.

Novus Biologicals offers many ABCA1 reagents for your research needs including:


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