p53 Products

Antibodies
p53 Antibody (PAb 240)
p53 Antibody (PAb 240)
NB200-103
Species: Hu, Mu, Rt, Ye, Xp(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready
Host: Mouse Monoclonal
Antibody Pairs
p53 Antibody Pair
p53 Antibody Pair
H00007157-PW2
Species: Hu
Applications: WB, IP
ELISA Kits
p53 ELISA Kit
p53 ELISA Kit
NBP1-91257
Species: Hu
Applications: ELISA
Kits
p53 Colorimetric Assay Kit
p53 Colorimetric Assay Kit
KA1351
Applications: Func
Lysates
p53 Overexpression Lysate (De ...
p53 Overexpression Lysate (Denatured)
H00007157-T01
Species: Hu
Applications: WB
p53 Overexpression Lysate (Na ...
p53 Overexpression Lysate (Native)
NBL1-17203
Applications: WB
p53 Overexpression Lysate (Na ...
p53 Overexpression Lysate (Native)
NBP2-11392
Applications: WB
Proteins
Recombinant Human p53 Protein ...
Recombinant Human p53 Protein
H00007157-P02
Species: Hu
Applications: WB, ELISA, PA
p53 Recombinant Protein Antig ...
p53 Recombinant Protein Antigen
NBP2-56234PEP
Species: Hu
Applications: B/N, Ctrl
Recombinant Human p53 Protein ...
Recombinant Human p53 Protein
H00007157-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
p53 RNAi
p53 RNAi
H00007157-R01V
Species: Hu
Applications: WB, RNAi, RNAi SP
p53 RNAi
p53 RNAi
H00007157-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

p53 is a stress-regulated transcription factor that was first identified as an SV40 large T antigen-binding protein. It plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. This antibody can be used for the specific detection of human p53 that is synthesized in the presence of p53 from other species.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Human
Mouse
Rat
Product By Gene ID 7157
Alternate Names
  • FLJ92943
  • Tumor suppressor p53
  • p53
  • transformation-related protein 53
  • Phosphoprotein p53
  • p53 tumor suppressor
  • Antigen NY-CO-13
  • P53cellular tumor antigen p53
  • LFS1TRP53
  • tumor protein p53

Bioinformatics Tool for p53

Discover related pathways, diseases and genes to p53. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related p53 Blog Posts

Check out the latest blog posts on p53.
Pathway Highlight: Which caspase substrates contribute to the morphological features associated with apoptosis?
Apoptosis, or programmed cell death, is controlled by a caspase signal cascade that activates downstream signals to induce the morphological changes used to differentiate apoptosis from other forms of cell death.  Novus Biologicals offers a variet...    Read more.
The role of p53 in UV radiation DNA damage and subsequent tumorogenesis
p53, the protein product of the tp53 gene, is one of the most widely studied tumor suppressor proteins in cancer research.  p53 is unique in that it demonstrates both tumor suppressive and tumor progressive properties depending on whether it is fu...    Read more.
MAPK8/JNK1 - A multifunctional kinase and drug target for cancer therapeutics
The c-Jun N-terminal kinase (JNK) family is a group of regulatory kinases with important functions in cell morphogenesis, inflammation, differentiation, and cell death (1). Aberrant activation of JNK family proteins in cancers has led to interest i...    Read more.
p53 - Investigating an important tumor suppressor
p53 is a tumor suppressor that has a central role in regulating cell cycle arrest, DNA repair, and apoptosis. p53 is widely studied for its role in cancer and is mutated or altered in more than half of all cancers (1). This widespread role in tumor...    Read more.
ATM - detecting and responding to DNA damage
Ataxia telangiectasia mutated (ATM) is essential for the maintenance of genomic stability. ATM is a 370 kDa serine-threonine kinase that is constitutively expressed in various tissues. Although primarily nuclear, ATM is also found at lower levels...    Read more.
NOXA - a BH3-only protein balancing cell death decisions
Noxa is a BH3-only protein involved in regulating cell death decisions. Noxa is a primary p53-response gene and is upregulated in response to p53 overexpression or DNA damage. Noxa can also be induced by alternative mechanisms including through a ...    Read more.
p73: An Important Tumor Suppressor Cousin of p53
p73 has been identified as a long-lost cousin of the p53 tumor suppressor protein. It has high homology with both p53 and with p63, a gene implicated in the maintenance of epithelial stem cells. The presence of significant homology between the DNA-bin...    Read more.
PRMT6: One Function, Many Roles
Protein arginine methylation is a prevalent posttranslational modification in eukaryotic cells. It regulates RNA processing, trafficking and nascent pre-RNA metabolism, receptor-mediated signal transduction, and transcriptional activation processes. P...    Read more.
Nanog is a Master Controller of ES cell Pluripotency
Nanog, a homeodomain (HD) transcription factor, plays a critical role in the maintenance of embryonic stem (ES) cell self-renewal. Transcription regulator involved in inner cell mass and ES cell proliferation and self-renewal. Imposes pluripotency on...    Read more.
p14 ARF is an Important Tumor Suppressor
The p14ARF (Alternative Reading Frame) tumor suppressor is a protein product of the alternative reading frame (ARF) of the human INK4a locus which regulates a series of cell cycle regulatory proteins to promote cell cycle arrest in response to abnorma...    Read more.
No Monkey Business: APE1 is a Critical DNA Repair Enzyme
APE1 (aka. HAP1, /Ref-1 or APEX) the mammalian ortholog of Escherichia coli Xth is a multifunctional protein possessing both DNA repair and transcriptional regulatory activity. APE1 acts essentially as master regulator of controlling cellular response...    Read more.
Beclin 1: Regulator of Autophagy and Apoptosis
Beclin 1 is the mammalian orthologue of the yeast Apg6/Vps30 gene. Beclin 1 can complement the defect in autophagy present in apg6 yeast strains and stimulate autophagy when overexpressed in mammalian cells (1) and can bind to Bcl2, an important regul...    Read more.
S100A6: Playing Roles in Cancer, Apoptosis & Transcription Regulation
S100A6 antibodies detect a small calcium binding protein with 2 EF-hand structures and belongs to the S100 family. Calcium binding induces a conformational change of the protein which in turn permits its interaction with several target proteins. It is...    Read more.
Recent Developments in p53 Antibody Research
P53 is a stress-activated transcription factor, encoded by the TP53 gene. An important tumor suppressor, the protein mediates cellular growth and proliferation, regulating proteins involved in the stress-response. In p53 antibody studies, the protein...    Read more.
The Heat is On: Heat Shock Proteins and the Link to Cancer
Novus Biologicals offers an extensive antibody catalog targeting heat shock proteins (HSPs). A large protein group covering a number of families, the HSPs are functionally related by their dramatic upregulation in response to stress. Stress triggers m...    Read more.
The Link Between Base Excision Repair and Cancer Antibodies
Base excision repair (BER) is the most fundamental DNA repair mechanism, dealing with alterations arising in individual DNA bases during cellular metabolism. We at Novus Biologicals have a large BER antibody database, which has proven important in var...    Read more.
Read more p53 related blogs.