HERC2 Products


HERC2 (HECT domain and RCC1-like domain-containing protein 2) belongs to the HERC family of ubiquitin ligases. A single nucleotide polymorphism (SNP) in an evolutionarily conserved region of the HERC2 gene is associated with blue eye color. Additionally, it has been reported that gene-gene interactions between HERC2, OCA2, and MC1R may influence eye, skin, and hair color.


Entrez Human
Uniprot Human
Product By Gene ID 8924
Alternate Names
  • EC 6.3.2
  • SHEP1
  • EC 6.3.2.-
  • HECT domain and RCC1-like domain-containing protein 2
  • probable E3 ubiquitin-protein ligase HERC2
  • p528
  • E3 ubiquitin-protein ligase HERC2
  • jdf2
  • KIAA0393
  • D15F37S1
  • DKFZp547P028
  • hect domain and RLD 2

PTMs for HERC2

Learn more about PTMs related to HERC2.


Bioinformatics Tool for HERC2

Discover related pathways, diseases and genes to HERC2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.