5-HT4 Antibody [DyLight 650]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 650

5-HT4 Antibody [DyLight 650] Summary

Immunogen
A synthetic peptide made to a C-terminal portion of the human 5HT4 Receptor protein (between residues 350-400) [UniProt Q13639]
Localization
Cell membrane; Multi-pass membrane protein. Endosome. Note: Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HTR4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
Application Notes
This 5HT4 Receptor antibody is useful for Immunocytochemistry/Immunofluorescence where cytoplasmic staining is observed in HeLa cells.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for 5-HT4 Antibody [DyLight 650]

  • 5HT4
  • 5-HT4
  • 5-HT-4
  • 5-HT4R
  • 5-hydroxytryptamine (serotonin) receptor 4,5-hydroxytryptamine receptor 4,5-HT45-hydroxytryptamine4 receptor
  • cardiac 5-HT4 receptor
  • HTR4
  • Serotonin receptor 4

Background

The 5HT4 receptor (5-HT4R) is a member of the serotonin receptors. In response to serotonin (5HT) these G protein coupled receptors cause an increase in cAMP production. It is a glycosylated, transmembrane protein found in the central and peripheral nervous system. Multiple transcripts with variant C-terminal sequnces have been described. The significance of SNP variants of 5HT4 receptors in mental diseases is a controversial topic (PMID:19328558, 19892407), while other SNP variants have been associated with asthma.( PMID:21382128). Additional research show that the early presence of these receptors in the dorsomedial nuclei of prenatal hypothalamus may indicate a crucial role in fetal development. (PMID:20538346)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol HTR4
Entrez