Hu, Bt, Bv, Ca, Eq, GP, Ha, Rb, Chicken, Primate, Opossum, Turkey, MonkeyApplications:
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Host: Mouse Monoclonal
Applications: WB, ELISA, PA
The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop. 5-HT4 receptor expression has been documented primarily in the brain, and in colon, heart, and vessel. An EST has been isolated from a human cancerous nerve library.
|Product By Gene ID
- Serotonin receptor 4
- cardiac 5-HT4 receptor
- 5-hydroxytryptamine (serotonin) receptor 4,5-hydroxytryptamine receptor 4,5-HT45-hydroxytryptamine4 receptor
PTMs for 5-HT4
Learn more about PTMs related to 5-HT4.Methylation
Bioinformatics Tool for 5-HT4
Discover related pathways, diseases and genes to 5-HT4. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.