5-HT4 Products

Description

The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop. 5-HT4 receptor expression has been documented primarily in the brain, and in colon, heart, and vessel. An EST has been isolated from a human cancerous nerve library.

Bioinformatics

Entrez	15562 Mouse 25324 Rat 3360 Human
Uniprot	NP_000861 Human NP_000861.1 Human NP_955525 Human Q13639 Human
Product By Gene ID	3360
Alternate Names	5-HT-4 5-HT4R 5-hydroxytryptamine (serotonin) receptor 4,5-hydroxytryptamine receptor 4,5-HT45-hydroxytryptamine4 receptor cardiac 5-HT4 receptor Serotonin receptor 4

Research Areas for 5-HT4

Find related products by research area and learn more about each of the different research areas below.

Asthma
GPCR
Growth and Development
Neuronal Cell Markers
Neuroscience
Neurotransmission