ZNF350 Antibody - BSA Free

Western Blot: ZNF350 Antibody [NBP1-76344] - A-20 lysate with ZBRK1 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

ZNF350 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit ZNF350 Antibody - BSA Free (NBP1-76344) is a polyclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human ZBRK1. The immunogen is located within amino acids 410 - 460 of ZBRK1. Amino Acid Squence: KRIHTREKQEAKKVENPPAE
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ZNF350
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1 ug/ml
• Control Peptide:

  ZNF350 Peptide (NBP1-76344PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for ZNF350 Antibody - BSA Free

• Berg36
• BRF1zinc finger protein 36, C3H1 type-like 1
• Butyrate response factor 1
• cMG1
• ERF1ERF-1
• Protein TIS11B
• RNF162BEGF-response factor 1
• TIS11Bearly response factor Berg36
• zinc finger protein 36, C3H type-like 1
• zinc finger protein, C3H type, 36-like 1

Background

ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ZNF350
• Uniprot:
  • NP_067645(Human)