Reactivity | HuSpecies Glossary |
Applications | WB |
Clonality | Polyclonal |
Host | Sheep |
Conjugate | Unconjugated |
Concentration | LYOPH |
Immunogen | E. coli-derived recombinant human GADD45 alpha Met1-Arg165 Accession # P24522 |
Specificity | Detects human GADD45 alpha in Western blots. |
Source | N/A |
Isotype | IgG |
Clonality | Polyclonal |
Host | Sheep |
Gene | GADD45A |
Purity | Immunogen affinity purified |
Purity Statement | Antigen Affinity-purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative | No Preservative |
Concentration | LYOPH |
Purity | Immunogen affinity purified |
Reconstitution Instructions | Reconstitute at 0.2 mg/mL in sterile PBS. |
GADD45 alpha (Growth arrest and DNA damage-inducible protein 45 alpha) is a 19 kDa member of the GADD45 family of proteins. It is ubiquitously expressed, and induced by DNA damage. Upon induction, GADD45 alpha binds to PCNA, stimulates DNA excision repair, and initiates G2 cell cycle arrest. Human GADD45 alpha is 165 amino acids (aa) in length. It is reported to dimerize with GADD45-beta and -gamma , and to homo-dimerize, -trimerize and -tetramerize via residues 33‑61 and 133‑165. There is one splice variant that shows a Ser substitution for aa 14‑49. GADD45 alpha is 55% aa identical to GADD45-beta and -gamma , and shares 94% aa identity with mouse GADD45 alpha .
Secondary Antibodies |
Isotype Controls |
Diseases for GADD45 alpha Antibody (AF5510)Discover more about diseases related to GADD45 alpha Antibody (AF5510).
| Pathways for GADD45 alpha Antibody (AF5510)View related products by pathway.
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PTMs for GADD45 alpha Antibody (AF5510)Learn more about PTMs related to GADD45 alpha Antibody (AF5510).
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