VDR/NR1I1/Vitamin D Receptor Antibody

Images

 
Western Blot: VDR/NR1I1/Vitamin D Receptor Antibody [NBP1-51322] - Analysis of VDR (K45) pAb pAb at 1:500 dilutionLane1:Hela whole cell lysate(30ug)Lane2:HepG2 whole cell lysate(30ug)Lane3:DLD whole cell ...read more
Immunohistochemistry-Paraffin: VDR/NR1I1/Vitamin D Receptor Antibody [NBP1-51322] - Paraffin-embedded human breast carcinoma tissue at 1:100.
Western Blot: VDR/NR1I1/Vitamin D Receptor Antibody [NBP1-51322] - Analysis of VDR (K45) pAb in extracts from Jurkat cells.
Immunohistochemistry-Paraffin: VDR/NR1I1/Vitamin D Receptor Antibody [NBP1-51322] - Analyzes of VDR (K45) pAb in paraffin-embedded human breast carcinoma tissue.

Order Details


    • Catalog Number
      NBP1-51322
    • Availability
      Product Discontinued

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VDR/NR1I1/Vitamin D Receptor Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 11-60 of Human VDR.
Specificity
VDR (K45) pAb detects endogenous levels of VDR protein.
Clonality
Polyclonal
Host
Rabbit
Gene
VDR
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of VDR (K45) pAb in extracts from Jurkat cells.
Immunohistochemistry (IHC) analyzes of VDR (K45) pAb in paraffin-embedded human breast carcinoma tissue. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 27548154).
Theoretical MW
48 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NBP1-51322 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for VDR/NR1I1/Vitamin D Receptor Antibody

  • NR1I1
  • NR1I1Nuclear receptor subfamily 1 group I member 11,25-dihydroxyvitamin D3 receptor
  • VDR
  • vitamin D1,25- dihydroxyvitamin D3 receptor
  • vitamin D3 receptor

Background

The active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally-specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9- cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma and breast carcinoma cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for VDR/NR1I1/Vitamin D Receptor Antibody (NBP1-51322)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.


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(1)
WB
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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol VDR
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