VDR/NR1I1/Vitamin D Receptor Antibody

Western Blot: VDR/NR1I1/Vitamin D Receptor Antibody [H00007421-B01P] - Analysis of VDR expression in 293.

Immunocytochemistry/Immunofluorescence: VDR/NR1I1/Vitamin D Receptor Antibody [H00007421-B01P] - Analysis of purified antibody to VDR on HeLa cell. (antibody concentration 10 ug/ml)

Western Blot: VDR/NR1I1/Vitamin D Receptor Antibody [H00007421-B01P] - Analysis of VDR expression in transfected 293T cell line by VDR polyclonal antibody. Lane 1: VDR transfected lysate(46.97 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

VDR/NR1I1/Vitamin D Receptor Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: VDR (NP_000367.1, 1 a.a. - 427 a.a.) full-length human protein. MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
• Specificity: VDR - vitamin D (1,25- dihydroxyvitamin D3) receptor,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: VDR
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Antibody reactivity against transfected lysate in WB. It has also be used for IF and ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for VDR/NR1I1/Vitamin D Receptor Antibody

• NR1I1
• NR1I1Nuclear receptor subfamily 1 group I member 11,25-dihydroxyvitamin D3 receptor
• VDR
• vitamin D1,25- dihydroxyvitamin D3 receptor
• vitamin D3 receptor

Background

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: VDR
• Entrez:
  • 7421(Human)
• Uniprot:
  • NP_000367.1(Human)